STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NBR_LOCUS12374Histone-lysine N-methyltransferase. (180 aa)    
Predicted Functional Partners:
NBR_LOCUS14987
Uncharacterized protein.
   
 
 0.917
NBR_LOCUS13601
SET domain-containing protein.
     
 0.906
NBR_LOCUS14352
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
     
 0.905
NBR_LOCUS10188
Histone-lysine N-methyltransferase met-2 (inferred by orthology to a C. elegans protein).
     
 0.874
NBR_LOCUS14344
Histone-lysine N-methyltransferase.
   
 
 0.873
NBR_LOCUS20519
Uncharacterized protein.
   
 
 0.865
NBR_LOCUS16488
PHD domain-containing protein.
     
 0.861
NBR_LOCUS8671
Histone-lysine N-methyltransferase.
     
 0.861
NBR_LOCUS12625
Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.846
NBR_LOCUS15847
Histone H4 (inferred by orthology to a zebrafish protein); Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
   
 0.845
Your Current Organism:
Nippostrongylus brasiliensis
NCBI taxonomy Id: 27835
Other names: N. brasiliensis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.