NBR_LOCUS16295 protein (Nippostrongylus brasiliensis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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NBR_LOCUS16295

LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family. (497 aa)

Predicted Functional Partners:

NBR_LOCUS2697

0.688

NBR_LOCUS5681

0.522

NBR_LOCUS6029

0.522

NBR_LOCUS10916

0.522

NBR_LOCUS13815

0.522

NBR_LOCUS15806

0.522

NBR_LOCUS21763

0.522

NBR_LOCUS6028

0.510

NBR_LOCUS8170

0.475

NBR_LOCUS12246

0.457

Your Current Organism:

Nippostrongylus brasiliensis

NCBI taxonomy Id: 27835
Other names: N. brasiliensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NBR_LOCUS10916	NBR_LOCUS16295	A0A0N4Y4R5	A0A0N4YHF7	HintN domain-containing protein.	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	0.522
NBR_LOCUS10916	NBR_LOCUS2697	A0A0N4Y4R5	A0A0N4XJJ4	HintN domain-containing protein.	LIMR family protein (inferred by orthology to a C. elegans protein).	0.522
NBR_LOCUS12246	NBR_LOCUS16295	A0A158R0P3	A0A0N4YHF7	S-phase kinase-associated protein 2 (inferred by orthology to a human protein).	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	0.457
NBR_LOCUS12246	NBR_LOCUS2697	A0A158R0P3	A0A0N4XJJ4	S-phase kinase-associated protein 2 (inferred by orthology to a human protein).	LIMR family protein (inferred by orthology to a C. elegans protein).	0.457
NBR_LOCUS13815	NBR_LOCUS16295	A0A0N4YBH6	A0A0N4YHF7	Uncharacterized protein.	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	0.522
NBR_LOCUS13815	NBR_LOCUS2697	A0A0N4YBH6	A0A0N4XJJ4	Uncharacterized protein.	LIMR family protein (inferred by orthology to a C. elegans protein).	0.522
NBR_LOCUS15806	NBR_LOCUS16295	A0A0N4YG82	A0A0N4YHF7	Warthog protein 1 (inferred by orthology to a C. elegans protein).	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	0.522
NBR_LOCUS15806	NBR_LOCUS2697	A0A0N4YG82	A0A0N4XJJ4	Warthog protein 1 (inferred by orthology to a C. elegans protein).	LIMR family protein (inferred by orthology to a C. elegans protein).	0.522
NBR_LOCUS16295	NBR_LOCUS10916	A0A0N4YHF7	A0A0N4Y4R5	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	HintN domain-containing protein.	0.522
NBR_LOCUS16295	NBR_LOCUS12246	A0A0N4YHF7	A0A158R0P3	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	S-phase kinase-associated protein 2 (inferred by orthology to a human protein).	0.457
NBR_LOCUS16295	NBR_LOCUS13815	A0A0N4YHF7	A0A0N4YBH6	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Uncharacterized protein.	0.522
NBR_LOCUS16295	NBR_LOCUS15806	A0A0N4YHF7	A0A0N4YG82	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Warthog protein 1 (inferred by orthology to a C. elegans protein).	0.522
NBR_LOCUS16295	NBR_LOCUS21763	A0A0N4YHF7	A0A0N4YWZ0	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Uncharacterized protein.	0.522
NBR_LOCUS16295	NBR_LOCUS2697	A0A0N4YHF7	A0A0N4XJJ4	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	LIMR family protein (inferred by orthology to a C. elegans protein).	0.688
NBR_LOCUS16295	NBR_LOCUS5681	A0A0N4YHF7	A0A0N4XT07	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Uncharacterized protein.	0.522
NBR_LOCUS16295	NBR_LOCUS6028	A0A0N4YHF7	A0A0N4XTS1	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Uncharacterized protein.	0.510
NBR_LOCUS16295	NBR_LOCUS6029	A0A0N4YHF7	A0A0N4XTS2	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Warthog protein 6 (inferred by orthology to a C. elegans protein).	0.522
NBR_LOCUS16295	NBR_LOCUS8170	A0A0N4YHF7	A0A0N4XYK1	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	Uncharacterized protein.	0.475
NBR_LOCUS21763	NBR_LOCUS16295	A0A0N4YWZ0	A0A0N4YHF7	Uncharacterized protein.	LIMR family protein (inferred by orthology to a C. elegans protein); Belongs to the LIMR family.	0.522
NBR_LOCUS21763	NBR_LOCUS2697	A0A0N4YWZ0	A0A0N4XJJ4	Uncharacterized protein.	LIMR family protein (inferred by orthology to a C. elegans protein).	0.522

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.749

expected number of edges:

15

PPI enrichment p-value:

6.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034728

Nucleosome organization

4 of 69

2.32

2.9

7.50e-06

GO:0006334

Nucleosome assembly

3 of 33

2.51

2.42

8.06e-05

GO:0031497

Chromatin assembly

4 of 130

2.04

2.38

3.52e-05

GO:0006325

Chromatin organization

5 of 306

1.77

2.26

1.48e-05

GO:0051276

Chromosome organization

6 of 534

1.6

2.14

6.62e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003682

Chromatin binding

6 of 252

1.93

3.48

2.66e-08

GO:0031492

Nucleosomal DNA binding

3 of 12

2.95

3.16

6.17e-06

GO:0030527

Structural constituent of chromatin

3 of 12

2.95

3.16

6.17e-06

GO:0046982

Protein heterodimerization activity

3 of 115

1.97

1.65

0.0010

GO:0005515

Protein binding

8 of 2974

0.98

1.04

6.58e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000785

Chromatin

6 of 204

2.02

3.97

4.07e-09

GO:0000786

Nucleosome

3 of 20

2.73

3.16

5.15e-06

GO:0005694

Chromosome

7 of 542

1.66

3.04

4.07e-09

GO:0005700

Polytene chromosome

3 of 165

1.81

1.56

0.0011

GO:0140513

Nuclear protein-containing complex

5 of 743

1.38

1.53

7.98e-05

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36760483

(2022) Sympatry of genetic lineages of Parisotomanotabilis s. l. (Collembola, Isotomidae) in the East European Plain.

2 of 2

3.55

2.59

6.42e-05

PMID:31919378

(2020) Rapid and cost-effective generation of single specimen multilocus barcoding data from whole arthropod communities by multiple levels of multiplexing.

2 of 2

3.55

2.59

6.42e-05

PMID:28397786

(2017) Cretaceous origin of the unique prey-capture apparatus in mega-diverse genus: stem lineage of Steninae rove beetles discovered in Burmese amber.

2 of 2

3.55

2.59

6.42e-05

PMID:28170395

(2017) Genetic structure and distribution of Parisotoma notabilis (Collembola) in Europe: Cryptic diversity, split of lineages and colonization patterns.

2 of 2

3.55

2.59

6.42e-05

PMID:34542224

(2022) Delete and survive: strategies of programmed genetic material elimination in eukaryotes.

2 of 6

3.08

2.56

6.42e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2638

Mixed, incl. Histone deacetylase complex, and Structural constituent of chromatin

4 of 79

2.26

2.71

1.46e-05

CL:2650

Structural constituent of chromatin, and Set1C/COMPASS complex

3 of 21

2.71

2.7

3.08e-05

CL:2652

Structural constituent of chromatin, and Set1C/COMPASS complex

2 of 16

2.65

1.5

0.0033

CL:3032

Mixed, incl. Chromo/chromo shadow domain, and Transcriptional Regulation by E2F6

2 of 56

2.11

0.88

0.0325

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8878171

Transcriptional regulation by RUNX1

4 of 207

1.84

2.02

0.00010

MAP-983231

Factors involved in megakaryocyte development and platelet production

3 of 99

2.03

1.76

0.00067

MAP-8936459

RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

3 of 133

1.91

1.57

0.0013

MAP-212436

Generic Transcription Pathway

6 of 1073

1.3

1.39

0.00010

MAP-73857

RNA Polymerase II Transcription

6 of 1198

1.25

1.32

0.00010

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000786

Nucleosome

3 of 12

2.95

3.25

4.25e-06

GOCC:0000785

Chromatin

5 of 186

1.98

3.01

9.07e-07

GOCC:0032991

Protein-containing complex

6 of 3032

0.85

0.62

0.0054

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0158

Chromosome

3 of 31

2.54

2.99

7.81e-06

KW-0539

Nucleus

6 of 495

1.64

2.59

2.09e-07

KW-0238

DNA-binding

5 of 371

1.68

2.37

2.84e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000164

Histone H3/CENP-A

3 of 5

3.33

3.38

3.11e-06

IPR007125

Histone H2A/H2B/H3

3 of 8

3.13

3.26

4.58e-06

IPR009072

Histone-fold

3 of 25

2.63

2.52

6.05e-05

IPR023780

Chromo domain

2 of 23

2.49

1.03

0.0198

IPR016197

Chromo-like domain superfamily

2 of 30

2.38

0.99

0.0229

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00428

Histone H3

3 of 5

3.33

3.9

4.21e-07

SM00298

Chromatin organization modifier domain

2 of 30

2.38

1.23

0.0088

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