NBR_LOCUS18784 protein (Nippostrongylus brasiliensis)

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

NBR_LOCUS18784

RING-type domain-containing protein. (222 aa)

Predicted Functional Partners:

NBR_LOCUS596

0.929

NBR_LOCUS597

0.929

NBR_LOCUS1193

0.929

NBR_LOCUS3389

0.929

NBR_LOCUS3562

0.929

NBR_LOCUS2302

0.578

NBR_LOCUS3179

0.578

NBR_LOCUS21537

0.578

NBR_LOCUS21648

0.578

NBR_LOCUS15512

0.483

Your Current Organism:

Nippostrongylus brasiliensis

NCBI taxonomy Id: 27835
Other names: N. brasiliensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NBR_LOCUS1193	NBR_LOCUS18784	A0A0N4XF89	A0A0N4YNH1	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	RING-type domain-containing protein.	0.929
NBR_LOCUS1193	NBR_LOCUS596	A0A0N4XF89	A0A0N4XDJ6	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	Uncharacterized protein.	0.459
NBR_LOCUS1193	NBR_LOCUS597	A0A0N4XF89	A0A0N4XDJ7	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	0.410
NBR_LOCUS15512	NBR_LOCUS18784	A0A0N4YFH7	A0A0N4YNH1	Uncharacterized protein.	RING-type domain-containing protein.	0.483
NBR_LOCUS18784	NBR_LOCUS1193	A0A0N4YNH1	A0A0N4XF89	RING-type domain-containing protein.	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	0.929
NBR_LOCUS18784	NBR_LOCUS15512	A0A0N4YNH1	A0A0N4YFH7	RING-type domain-containing protein.	Uncharacterized protein.	0.483
NBR_LOCUS18784	NBR_LOCUS21537	A0A0N4YNH1	A0A0N4YWB4	RING-type domain-containing protein.	Headcase domain-containing protein.	0.578
NBR_LOCUS18784	NBR_LOCUS21648	A0A0N4YNH1	A0A3P7BGE6	RING-type domain-containing protein.	Uncharacterized protein.	0.578
NBR_LOCUS18784	NBR_LOCUS2302	A0A0N4YNH1	A0A0N4XIE9	RING-type domain-containing protein.	Headcase domain-containing protein.	0.578
NBR_LOCUS18784	NBR_LOCUS3179	A0A0N4YNH1	A0A0N4XKX8	RING-type domain-containing protein.	Headcase domain-containing protein.	0.578
NBR_LOCUS18784	NBR_LOCUS3389	A0A0N4YNH1	A0A0N4XLI6	RING-type domain-containing protein.	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	0.929
NBR_LOCUS18784	NBR_LOCUS3562	A0A0N4YNH1	A0A0N4XM09	RING-type domain-containing protein.	Raptor_N domain-containing protein.	0.929
NBR_LOCUS18784	NBR_LOCUS596	A0A0N4YNH1	A0A0N4XDJ6	RING-type domain-containing protein.	Uncharacterized protein.	0.929
NBR_LOCUS18784	NBR_LOCUS597	A0A0N4YNH1	A0A0N4XDJ7	RING-type domain-containing protein.	Regulatory-associated protein of mTOR (inferred by orthology to a human protein).	0.929
NBR_LOCUS21537	NBR_LOCUS18784	A0A0N4YWB4	A0A0N4YNH1	Headcase domain-containing protein.	RING-type domain-containing protein.	0.578
NBR_LOCUS21648	NBR_LOCUS18784	A0A3P7BGE6	A0A0N4YNH1	Uncharacterized protein.	RING-type domain-containing protein.	0.578
NBR_LOCUS21648	NBR_LOCUS2302	A0A3P7BGE6	A0A0N4XIE9	Uncharacterized protein.	Headcase domain-containing protein.	0.702
NBR_LOCUS2302	NBR_LOCUS18784	A0A0N4XIE9	A0A0N4YNH1	Headcase domain-containing protein.	RING-type domain-containing protein.	0.578
NBR_LOCUS2302	NBR_LOCUS21648	A0A0N4XIE9	A0A3P7BGE6	Headcase domain-containing protein.	Uncharacterized protein.	0.702
NBR_LOCUS3179	NBR_LOCUS18784	A0A0N4XKX8	A0A0N4YNH1	Headcase domain-containing protein.	RING-type domain-containing protein.	0.578

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Network Stats

number of nodes:

11

number of edges:

21

average node degree:

3.82

avg. local clustering coefficient:

0.753

expected number of edges:

12

PPI enrichment p-value:

0.0158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016226

Iron-sulfur cluster assembly

6 of 28

2.5

5.09

8.56e-11

GO:0097428

Protein maturation by iron-sulfur cluster transfer

5 of 12

2.79

5.02

3.55e-10

GO:0106035

Protein maturation by [4Fe-4S] cluster transfer

2 of 5

2.77

1.33

0.0038

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051537

2 iron, 2 sulfur cluster binding

7 of 50

2.31

5.47

2.50e-12

GO:0051536

Iron-sulfur cluster binding

8 of 126

1.97

4.6

2.50e-12

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 71

1.79

1.11

0.0061

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

6 of 832

1.03

0.75

0.0052

GO:0043231

Intracellular membrane-bounded organelle

11 of 6169

0.42

0.33

0.0068

GO:0005737

Cytoplasm

11 of 5997

0.43

0.33

0.0068

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14737

Iron-sulfur cluster assembly, and BolA protein

10 of 44

2.52

9.63

1.73e-21

CL:14738

Mitochondrial iron-sulfur cluster biogenesis, and BolA protein

9 of 29

2.66

9.6

2.38e-20

CL:14741

Iron-sulfur cluster assembly, and Monothiol glutaredoxin-related

5 of 14

2.72

5.05

2.58e-10

CL:14781

BolA protein, and Glutaredoxin, PICOT-like

4 of 7

2.92

4.29

1.21e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

6 of 19

2.67

5.97

2.73e-12

MAP-9020591

Interleukin-12 signaling

2 of 3

2.99

1.53

0.0017

MAP-447115

Interleukin-12 family signaling

2 of 3

2.99

1.53

0.0017

MAP-1430728

Metabolism

7 of 1490

0.84

0.64

0.0028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

5 of 570

1.11

0.7

0.0144

GOCC:0005737

Cytoplasm

10 of 4259

0.54

0.37

0.0144

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01722

BolA-like protein

4 of 5

3.07

4.18

2.20e-08

PF01521

Iron-sulphur cluster biosynthesis

2 of 3

2.99

1.38

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036065

BolA-like superfamily

4 of 5

3.07

3.95

6.10e-08

IPR002634

BolA protein

4 of 5

3.07

3.95

6.10e-08

IPR044200

Uncharacterized protein At5g03900-like

2 of 2

3.17

1.36

0.0035

IPR035903

HesB-like domain superfamily

2 of 3

2.99

1.36

0.0035

IPR017870

FeS cluster insertion, C-terminal, conserved site

2 of 2

3.17

1.36

0.0035

(more ...)

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