STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NBR_LOCUS19801E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (106 aa)    
Predicted Functional Partners:
NBR_LOCUS13874
E3 ubiquitin-protein ligase HECTD1 (inferred by orthology to a human protein).
   
  
 0.530
NBR_LOCUS10905
Cullin-5 (inferred by orthology to a human protein); Belongs to the cullin family.
   
    0.518
NBR_LOCUS10697
Uncharacterized protein.
    
 
 0.411
NBR_LOCUS10698
Ubiquitin-conjugating enzyme E2 1 (inferred by orthology to a C. elegans protein); Belongs to the ubiquitin-conjugating enzyme family.
    
 
 0.411
Your Current Organism:
Nippostrongylus brasiliensis
NCBI taxonomy Id: 27835
Other names: N. brasiliensis
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