NBR_LOCUS20052 protein (Nippostrongylus brasiliensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

NBR_LOCUS20052

Uncharacterized protein. (83 aa)

Predicted Functional Partners:

NBR_LOCUS6086

0.470

NBR_LOCUS14443

0.470

NBR_LOCUS14513

0.470

NBR_LOCUS15968

0.401

Your Current Organism:

Nippostrongylus brasiliensis

NCBI taxonomy Id: 27835
Other names: N. brasiliensis

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NBR_LOCUS14443	NBR_LOCUS20052	A0A0N4YCY2	A0A0N4YS29	Kinesin light chain (inferred by orthology to a D. melanogaster protein).	Uncharacterized protein.	0.470
NBR_LOCUS14513	NBR_LOCUS20052	A0A0N4YD39	A0A0N4YS29	Uncharacterized protein.	Uncharacterized protein.	0.470
NBR_LOCUS15968	NBR_LOCUS20052	A0A0N4YGM3	A0A0N4YS29	Uncharacterized protein.	Uncharacterized protein.	0.401
NBR_LOCUS20052	NBR_LOCUS14443	A0A0N4YS29	A0A0N4YCY2	Uncharacterized protein.	Kinesin light chain (inferred by orthology to a D. melanogaster protein).	0.470
NBR_LOCUS20052	NBR_LOCUS14513	A0A0N4YS29	A0A0N4YD39	Uncharacterized protein.	Uncharacterized protein.	0.470
NBR_LOCUS20052	NBR_LOCUS15968	A0A0N4YS29	A0A0N4YGM3	Uncharacterized protein.	Uncharacterized protein.	0.401
NBR_LOCUS20052	NBR_LOCUS6086	A0A0N4YS29	A0A0N4XTW4	Uncharacterized protein.	Tetratricopeptide repeat protein 19, mitochondrial (inferred by orthology to a human protein).	0.470
NBR_LOCUS6086	NBR_LOCUS20052	A0A0N4XTW4	A0A0N4YS29	Tetratricopeptide repeat protein 19, mitochondrial (inferred by orthology to a human protein).	Uncharacterized protein.	0.470

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.816

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001240

Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

3 of 21

2.78

2.06

0.00017

GO:0039528

Cytoplasmic pattern recognition receptor signaling pathway in response to virus

2 of 14

2.78

1.09

0.0107

GO:0038061

NIK/NF-kappaB signaling

2 of 30

2.45

0.82

0.0316

GO:0061709

Reticulophagy

2 of 38

2.35

0.81

0.0336

GO:0002218

Activation of innate immune response

2 of 36

2.37

0.81

0.0336

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035438

cyclic-di-GMP binding

2 of 2

3.63

1.68

0.00095

GO:0061507

2,3-cyclic GMP-AMP binding

2 of 4

3.32

1.62

0.0012

GO:0015459

Potassium channel regulator activity

3 of 98

2.11

1.44

0.0017

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005793

Endoplasmic reticulum-Golgi intermediate compartment

4 of 144

2.07

2.18

4.23e-05

GO:0055037

Recycling endosome

3 of 298

1.63

0.98

0.0094

GO:0033116

Endoplasmic reticulum-Golgi intermediate compartment membrane

2 of 70

2.08

0.89

0.0217

GO:0000421

Autophagosome membrane

2 of 66

2.11

0.89

0.0217

GO:0030134

COPII-coated ER to Golgi transport vesicle

2 of 117

1.86

0.7

0.0465

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7052

Mixed, incl. PDPK1 family, and CISK, PX domain

4 of 10

3.23

4.29

1.56e-08

CL:28606

Mixed, incl. Fork head domain conserved site1, and Interferon regulatory factor

3 of 89

2.15

1.49

0.0014

CL:28620

Mixed, incl. cyclic-di-GMP binding, and Regulation of MyD88-dependent toll-like receptor signaling pathway

2 of 11

2.89

1.37

0.0033

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04068

FoxO signaling pathway

4 of 477

1.55

1.36

0.00070

map04623

Cytosolic DNA-sensing pathway

2 of 96

1.94

0.85

0.0238

map04621

NOD-like receptor signaling pathway

3 of 745

1.23

0.61

0.0413

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3270619

IRF3-mediated induction of type I IFN

2 of 8

3.02

1.41

0.0028

MAP-3249367

STAT6-mediated induction of chemokines

2 of 12

2.85

1.41

0.0028

MAP-3134975

Regulation of innate immune responses to cytosolic DNA

2 of 17

2.7

1.34

0.0037

MAP-1834941

STING mediated induction of host immune responses

2 of 19

2.65

1.33

0.0037

MAP-2672351

Stimuli-sensing channels

4 of 394

1.63

1.19

0.0028

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF15009

Transmembrane protein 173

2 of 2

3.63

1.65

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR047191

Stimulator of interferon genes protein, C-terminal

2 of 2

3.63

1.4

0.0031

IPR038623

Stimulator of interferon genes protein, C-terminal domain superfamily

2 of 2

3.63

1.4

0.0031

IPR037900

CISK, PX domain

2 of 2

3.63

1.4

0.0031

IPR029158

Stimulator of interferon genes protein

2 of 2

3.63

1.4

0.0031

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