STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NBR_LOCUS21128CYCLIN domain-containing protein; Belongs to the cyclin family. (180 aa)    
Predicted Functional Partners:
NBR_LOCUS19357
DH domain-containing protein.
    
 0.951
NBR_LOCUS16308
Uncharacterized protein; Belongs to the actin family.
    
 0.857
NBR_LOCUS21285
WD_REPEATS_REGION domain-containing protein.
   
 0.853
NBR_LOCUS8248
Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family.
   
 0.847
NBR_LOCUS12258
Actin-depolymerizing factor 1 (inferred by orthology to a C. elegans protein); Belongs to the actin-binding proteins ADF family.
   
 0.847
NBR_LOCUS19374
Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.
   
 0.843
NBR_LOCUS10994
Actin-related protein 3 (inferred by orthology to a C. elegans protein); Belongs to the actin family.
   
 0.827
NBR_LOCUS7969
F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.
   
 0.804
NBR_LOCUS16605
Dynactin subunit 6 (inferred by orthology to a C. elegans protein).
    
 0.804
NBR_LOCUS7376
Actin-interacting protein 1 (inferred by orthology to a D. melanogaster protein).
   
 0.802
Your Current Organism:
Nippostrongylus brasiliensis
NCBI taxonomy Id: 27835
Other names: N. brasiliensis
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