NBR_LOCUS22153 protein (Nippostrongylus brasiliensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

NBR_LOCUS22153

Uncharacterized protein. (430 aa)

Predicted Functional Partners:

NBR_LOCUS17931

0.626

NBR_LOCUS19805

0.626

NBR_LOCUS8599

0.597

NBR_LOCUS3963

0.555

NBR_LOCUS4636

0.555

NBR_LOCUS21919

0.555

NBR_LOCUS8596

0.555

NBR_LOCUS14658

0.554

NBR_LOCUS20789

0.554

NBR_LOCUS10940

0.483

Your Current Organism:

Nippostrongylus brasiliensis

NCBI taxonomy Id: 27835
Other names: N. brasiliensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NBR_LOCUS10940	NBR_LOCUS22153	A0A158QZZ1	A0A0N4YY30	Protein-serine/threonine kinase.	Uncharacterized protein.	0.483
NBR_LOCUS14658	NBR_LOCUS17931	A0A0N4YDG0	A0A0N4YLE6	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Uncharacterized protein.	0.948
NBR_LOCUS14658	NBR_LOCUS19805	A0A0N4YDG0	A0A0N4YRD2	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Bile acid receptor (inferred by orthology to a human protein).	0.948
NBR_LOCUS14658	NBR_LOCUS21919	A0A0N4YDG0	A0A0N4YXE6	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Uncharacterized protein.	0.948
NBR_LOCUS14658	NBR_LOCUS22153	A0A0N4YDG0	A0A0N4YY30	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Uncharacterized protein.	0.554
NBR_LOCUS14658	NBR_LOCUS3963	A0A0N4YDG0	A0A0N4XN60	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Uncharacterized protein.	0.948
NBR_LOCUS14658	NBR_LOCUS4636	A0A0N4YDG0	A0A0N4XQ33	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Nuclear hormone receptor family member nhr-2 (inferred by orthology to a C. elegans protein).	0.948
NBR_LOCUS14658	NBR_LOCUS8596	A0A0N4YDG0	A0A158QYJ8	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	Nuclear hormone receptor family member nhr-48 (inferred by orthology to a C. elegans protein).	0.948
NBR_LOCUS14658	NBR_LOCUS8599	A0A0N4YDG0	A0A158QYJ9	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	NR LBD domain-containing protein.	0.739
NBR_LOCUS17931	NBR_LOCUS14658	A0A0N4YLE6	A0A0N4YDG0	Uncharacterized protein.	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	0.948
NBR_LOCUS17931	NBR_LOCUS22153	A0A0N4YLE6	A0A0N4YY30	Uncharacterized protein.	Uncharacterized protein.	0.626
NBR_LOCUS17931	NBR_LOCUS8599	A0A0N4YLE6	A0A158QYJ9	Uncharacterized protein.	NR LBD domain-containing protein.	0.995
NBR_LOCUS19805	NBR_LOCUS14658	A0A0N4YRD2	A0A0N4YDG0	Bile acid receptor (inferred by orthology to a human protein).	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	0.948
NBR_LOCUS19805	NBR_LOCUS22153	A0A0N4YRD2	A0A0N4YY30	Bile acid receptor (inferred by orthology to a human protein).	Uncharacterized protein.	0.626
NBR_LOCUS19805	NBR_LOCUS8599	A0A0N4YRD2	A0A158QYJ9	Bile acid receptor (inferred by orthology to a human protein).	NR LBD domain-containing protein.	0.995
NBR_LOCUS20789	NBR_LOCUS22153	A0A0N4YU66	A0A0N4YY30	RNA_GG_bind domain-containing protein.	Uncharacterized protein.	0.554
NBR_LOCUS21919	NBR_LOCUS14658	A0A0N4YXE6	A0A0N4YDG0	Uncharacterized protein.	Nuclear hormone receptor family member nhr-19 (inferred by orthology to a C. elegans protein).	0.948
NBR_LOCUS21919	NBR_LOCUS22153	A0A0N4YXE6	A0A0N4YY30	Uncharacterized protein.	Uncharacterized protein.	0.555
NBR_LOCUS21919	NBR_LOCUS4636	A0A0N4YXE6	A0A0N4XQ33	Uncharacterized protein.	Nuclear hormone receptor family member nhr-2 (inferred by orthology to a C. elegans protein).	0.482
NBR_LOCUS21919	NBR_LOCUS8599	A0A0N4YXE6	A0A158QYJ9	Uncharacterized protein.	NR LBD domain-containing protein.	0.956

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.885

expected number of edges:

10

PPI enrichment p-value:

0.233

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046907

Intracellular transport

5 of 521

1.35

0.95

0.0054

GO:0006886

Intracellular protein transport

4 of 319

1.46

0.92

0.0092

GO:0015031

Protein transport

5 of 823

1.15

0.74

0.0124

GO:0006606

Protein import into nucleus

2 of 40

2.06

0.74

0.0427

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043227

Membrane-bounded organelle

11 of 7441

0.54

0.43

0.0011

GO:0043229

Intracellular organelle

11 of 7650

0.52

0.42

0.0011

GO:0005737

Cytoplasm

10 of 6797

0.53

0.41

0.0031

GO:0043231

Intracellular membrane-bounded organelle

10 of 6999

0.52

0.4

0.0033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3521

LAG1, DNA binding, and Protein of unknown function DUF6699

2 of 5

2.97

1.61

0.0012

CL:2008

Mixed, incl. Exportin-1/5, and Zinc finger, RanBP2-type

2 of 5

2.97

1.61

0.0012

CL:1954

Nuclear pore

3 of 32

2.34

1.58

0.0011

CL:15982

Mostly uncharacterized, incl. Serine-type endopeptidase activity, and Multifunctional anion exchangers

3 of 145

1.68

1.17

0.0035

CL:16106

Mixed, incl. Multifunctional anion exchangers, and Tyrosine/serine-protein phosphatase IphP-type

2 of 34

2.14

1.1

0.0085

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-68875

Mitotic Prophase

3 of 53

2.12

1.62

0.00076

MAP-68886

M Phase

4 of 175

1.72

1.47

0.00070

MAP-2980766

Nuclear Envelope Breakdown

2 of 26

2.25

0.92

0.0198

MAP-69278

Cell Cycle, Mitotic

4 of 630

1.17

0.66

0.0253

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040159

Suppressor of hairless-like

2 of 2

3.37

1.39

0.0032

IPR037095

RBP-J/Cbf11, DNA binding domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036358

Beta-trefoil domain superfamily

2 of 2

3.37

1.39

0.0032

IPR015351

RBP-J/Cbf11/Cbf12, DNA binding

2 of 2

3.37

1.39

0.0032

IPR015350

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.39

0.0032

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01268

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.93

0.00034

SM01267

LAG1, DNA binding

2 of 2

3.37

1.93

0.00034

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