NBR_LOCUS12094 protein (Nippostrongylus brasiliensis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

NBR_LOCUS12094

Uncharacterized protein; Belongs to the cytochrome P450 family. (272 aa)

Predicted Functional Partners:

NBR_LOCUS10570

0.938

NBR_LOCUS10571

0.938

NBR_LOCUS15448

0.894

NBR_LOCUS17624

0.847

NBR_LOCUS8451

0.817

NBR_LOCUS13785

0.783

NBR_LOCUS15487

0.783

NBR_LOCUS10643

0.778

NBR_LOCUS12211

0.771

NBR_LOCUS17609

0.764

Your Current Organism:

Nippostrongylus brasiliensis

NCBI taxonomy Id: 27835
Other names: N. brasiliensis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NBR_LOCUS10570	NBR_LOCUS10571	A0A0N4Y3Z1	A0A0N4Y3Z2	Uncharacterized protein.	Uncharacterized protein.	0.997
NBR_LOCUS10570	NBR_LOCUS10643	A0A0N4Y3Z1	A0A0N4Y448	Uncharacterized protein.	Probable cytochrome P450 CYP44 (inferred by orthology to a C. elegans protein); Belongs to the cytochrome P450 family.	0.950
NBR_LOCUS10570	NBR_LOCUS12094	A0A0N4Y3Z1	A0A3P7B8Z3	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.938
NBR_LOCUS10570	NBR_LOCUS13785	A0A0N4Y3Z1	A0A0N4YBF2	Uncharacterized protein.	Uncharacterized protein.	0.486
NBR_LOCUS10570	NBR_LOCUS15448	A0A0N4Y3Z1	A0A0N4YFC1	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.416
NBR_LOCUS10570	NBR_LOCUS15487	A0A0N4Y3Z1	A0A0N4YFF5	Uncharacterized protein.	Uncharacterized protein.	0.486
NBR_LOCUS10570	NBR_LOCUS17609	A0A0N4Y3Z1	A0A0N4YKM5	Uncharacterized protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.996
NBR_LOCUS10570	NBR_LOCUS17624	A0A0N4Y3Z1	A0A0N4YKP0	Uncharacterized protein.	Uncharacterized protein.	0.513
NBR_LOCUS10570	NBR_LOCUS8451	A0A0N4Y3Z1	A0A158QYG3	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.831
NBR_LOCUS10571	NBR_LOCUS10570	A0A0N4Y3Z2	A0A0N4Y3Z1	Uncharacterized protein.	Uncharacterized protein.	0.997
NBR_LOCUS10571	NBR_LOCUS10643	A0A0N4Y3Z2	A0A0N4Y448	Uncharacterized protein.	Probable cytochrome P450 CYP44 (inferred by orthology to a C. elegans protein); Belongs to the cytochrome P450 family.	0.950
NBR_LOCUS10571	NBR_LOCUS12094	A0A0N4Y3Z2	A0A3P7B8Z3	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.938
NBR_LOCUS10571	NBR_LOCUS13785	A0A0N4Y3Z2	A0A0N4YBF2	Uncharacterized protein.	Uncharacterized protein.	0.486
NBR_LOCUS10571	NBR_LOCUS15448	A0A0N4Y3Z2	A0A0N4YFC1	Uncharacterized protein.	Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.	0.416
NBR_LOCUS10571	NBR_LOCUS15487	A0A0N4Y3Z2	A0A0N4YFF5	Uncharacterized protein.	Uncharacterized protein.	0.486
NBR_LOCUS10571	NBR_LOCUS17609	A0A0N4Y3Z2	A0A0N4YKM5	Uncharacterized protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.996
NBR_LOCUS10571	NBR_LOCUS17624	A0A0N4Y3Z2	A0A0N4YKP0	Uncharacterized protein.	Uncharacterized protein.	0.513
NBR_LOCUS10571	NBR_LOCUS8451	A0A0N4Y3Z2	A0A158QYG3	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.831
NBR_LOCUS10643	NBR_LOCUS10570	A0A0N4Y448	A0A0N4Y3Z1	Probable cytochrome P450 CYP44 (inferred by orthology to a C. elegans protein); Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.950
NBR_LOCUS10643	NBR_LOCUS10571	A0A0N4Y448	A0A0N4Y3Z2	Probable cytochrome P450 CYP44 (inferred by orthology to a C. elegans protein); Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.950

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

15

PPI enrichment p-value:

2.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006094

Gluconeogenesis

3 of 29

2.38

2.19

7.07e-05

GO:0044283

Small molecule biosynthetic process

8 of 672

1.44

2.18

5.43e-08

GO:1901607

Alpha-amino acid biosynthetic process

5 of 201

1.76

2.17

1.04e-05

GO:0006096

Glycolytic process

4 of 108

1.94

2.03

6.07e-05

GO:0019284

L-methionine salvage from S-adenosylmethionine

2 of 3

3.19

2.02

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016860

Intramolecular oxidoreductase activity

5 of 69

2.23

3.34

1.72e-07

GO:0004347

glucose-6-phosphate isomerase activity

3 of 3

3.37

3.26

1.28e-06

GO:0046570

Methylthioribulose 1-phosphate dehydratase activity

2 of 2

3.37

1.86

0.00044

GO:0043874

Acireductone synthase activity

2 of 2

3.37

1.86

0.00044

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.37

1.86

0.00044

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13634

L-serine biosynthetic process

3 of 11

2.8

2.33

5.40e-05

CL:13538

Mixed, incl. One carbon pool by folate, and De novo IMP biosynthetic process

4 of 59

2.2

2.19

5.40e-05

CL:14077

L-methionine salvage from S-adenosylmethionine, and S-methyl-5-thioribose kinase activity

2 of 5

2.97

1.3

0.0044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pda00030

Pentose phosphate pathway

2 of 70

1.82

0.76

0.0346

pda01200

Carbon metabolism

3 of 304

1.36

0.67

0.0346

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 86

2.04

2.17

3.83e-05

MAP-70326

Glucose metabolism

4 of 132

1.85

1.88

0.00010

MAP-70263

Gluconeogenesis

3 of 93

1.88

1.32

0.0023

MAP-977347

Serine biosynthesis

2 of 16

2.46

1.29

0.0043

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 144

1.69

1.14

0.0043

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 2

3.37

1.94

0.00032

KW-0324

Glycolysis

2 of 47

2.0

0.8

0.0309

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00342

Phosphoglucose isomerase

2 of 2

3.37

1.48

0.0022

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