| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| spo0A | spoIIAA | BL01518 | BL00776 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | 0.667 |
| spo0A | spoIIAB | BL01518 | BL00777 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.856 |
| spo0A | spoIIE | BL01518 | BL00506 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Serine phosphatase. | 0.852 |
| spo0A | spoIIGA | BL01518 | BL02254 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Protease SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. | 0.640 |
| spo0A | spoIIID | BL01518 | BL02501 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | Transcriptional regulator. | 0.829 |
| spo0A | spoIIP | BL01518 | BL02090 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | SpoIIP. | 0.543 |
| spo0A | spoIIR | BL01518 | BL03984 | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | SpoIIR. | 0.821 |
| spoIIAA | spo0A | BL00776 | BL01518 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.667 |
| spoIIAA | spoIIAB | BL00776 | BL00777 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | 0.999 |
| spoIIAA | spoIIE | BL00776 | BL00506 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | Serine phosphatase. | 0.918 |
| spoIIAA | spoIIGA | BL00776 | BL02254 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | Protease SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. | 0.929 |
| spoIIAA | spoIIID | BL00776 | BL02501 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | Transcriptional regulator. | 0.634 |
| spoIIAA | spoIIM | BL00776 | BL05250 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | SpoIIM; Required for complete septum migration and engulfment of the forespore compartment during sporulation. Required for stabilizing and recruiting of SpoIIP to the septal membrane. | 0.772 |
| spoIIAA | spoIIP | BL00776 | BL02090 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | SpoIIP. | 0.678 |
| spoIIAA | spoIIR | BL00776 | BL03984 | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | SpoIIR. | 0.867 |
| spoIIAB | spo0A | BL00777 | BL01518 | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | Two-component response regulator; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. | 0.856 |
| spoIIAB | spoIIAA | BL00777 | BL00776 | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | Anti-anti-sigma factor (antagonist of SpoIIAB); Belongs to the anti-sigma-factor antagonist family. | 0.999 |
| spoIIAB | spoIIE | BL00777 | BL00506 | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | Serine phosphatase. | 0.943 |
| spoIIAB | spoIIGA | BL00777 | BL02254 | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | Protease SpoIIGA; Probable aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE/spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR. | 0.973 |
| spoIIAB | spoIIID | BL00777 | BL02501 | Anti-sigma factor (antagonist of sigma-F) and serine kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition. | Transcriptional regulator. | 0.858 |
