| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fhs | metA | BL01370 | BL01365 | Formate tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.697 |
| fhs | metH | BL01370 | BL01308 | Formate tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.866 |
| fhs | yitJ | BL01370 | BL01307 | Formate tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Homocysteine S-methyltransferase. | 0.875 |
| hisI | hom | BL03413 | BL02137 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Homoserine dehydrogenase. | 0.448 |
| hisI | metA | BL03413 | BL01365 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.821 |
| hisI | metH | BL03413 | BL01308 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.423 |
| hisI | thrB | BL03413 | BL02135 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.410 |
| hisI | yclM | BL03413 | BL01851 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Aspartate kinase YclM; Belongs to the aspartokinase family. | 0.466 |
| hisI | yitJ | BL03413 | BL01307 | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Homocysteine S-methyltransferase. | 0.777 |
| hom | hisI | BL02137 | BL03413 | Homoserine dehydrogenase. | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.448 |
| hom | metA | BL02137 | BL01365 | Homoserine dehydrogenase. | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | 0.755 |
| hom | metH | BL02137 | BL01308 | Homoserine dehydrogenase. | Putative 5-methyltetrahydrofolate--homocysteine methyltransferase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.934 |
| hom | thrB | BL02137 | BL02135 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.997 |
| hom | yclM | BL02137 | BL01851 | Homoserine dehydrogenase. | Aspartate kinase YclM; Belongs to the aspartokinase family. | 0.829 |
| hom | yitJ | BL02137 | BL01307 | Homoserine dehydrogenase. | Homocysteine S-methyltransferase. | 0.954 |
| hom | yjcI | BL02137 | BL02660 | Homoserine dehydrogenase. | Cys/Met metabolism pyridoxal-phosphate-dependent enzymes. | 0.703 |
| hom | yjcJ | BL02137 | BL02659 | Homoserine dehydrogenase. | Putative Cystathionine beta-lyase. | 0.647 |
| hom | yrhB | BL02137 | BL02018 | Homoserine dehydrogenase. | Cystathionine gamma-lyase YrhB. | 0.647 |
| metA | fhs | BL01365 | BL01370 | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | Formate tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.697 |
| metA | hisI | BL01365 | BL03413 | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. | phosphoribosyl-AMP cyclohydrolase and phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.821 |