| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BL05279 | hemC | BL05279 | BL00625 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.982 |
| BL05279 | hemD | BL05279 | BL00626 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Uroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.925 |
| BL05279 | hemE | BL05279 | BL01072 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.716 |
| BL05279 | nasF | BL05279 | BL01771 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase. | 0.967 |
| BL05279 | sirA | BL05279 | BL02289 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Siroheme synthase SirA. | 0.618 |
| BL05279 | yjjA | BL05279 | BL00469 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Putative Uroporphyrinogen III synthase YjjA. | 0.765 |
| cysJ | nasF | BL01950 | BL01771 | Sulfite reductase (NADPH) hemoprotein beta-component CysJ; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | uroporphyrin-III C-methyltransferase. | 0.920 |
| cysJ | sirA | BL01950 | BL02289 | Sulfite reductase (NADPH) hemoprotein beta-component CysJ; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | Siroheme synthase SirA. | 0.730 |
| hemB | hemC | BL00627 | BL00625 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.999 |
| hemB | hemD | BL00627 | BL00626 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Uroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.993 |
| hemB | hemE | BL00627 | BL01072 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.884 |
| hemB | nasF | BL00627 | BL01771 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | uroporphyrin-III C-methyltransferase. | 0.968 |
| hemB | sirA | BL00627 | BL02289 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Siroheme synthase SirA. | 0.657 |
| hemB | yjjA | BL00627 | BL00469 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | Putative Uroporphyrinogen III synthase YjjA. | 0.765 |
| hemC | BL05279 | BL00625 | BL05279 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | 0.982 |
| hemC | hemB | BL00625 | BL00627 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. | 0.999 |
| hemC | hemD | BL00625 | BL00626 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Uroporphyrinogen III cosynthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.999 |
| hemC | hemE | BL00625 | BL01072 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.995 |
| hemC | nasD | BL00625 | BL01769 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Assimilatory nitrite reductase (subunit); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.448 |
| hemC | nasF | BL00625 | BL01771 | Porphobilinogen deaminase (hydroxymethylbilane synthase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | uroporphyrin-III C-methyltransferase. | 0.999 |