node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpC | dnaJ | BL03261 | BL02098 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.867 |
clpC | dnaK | BL03261 | BL02097 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.978 |
clpC | groEL | BL03261 | BL03283 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (chaperonin); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.764 |
clpC | groES | BL03261 | BL03284 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (chaperonin); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.828 |
clpC | grpE | BL03261 | BL02095 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.874 |
clpC | hrcA | BL03261 | BL02094 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.685 |
clpC | htpG | BL03261 | BL00247 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Class III heat-shock protein (molecular chaperone); Molecular chaperone. Has ATPase activity. | 0.798 |
clpC | rtpA | BL03261 | BL05022 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Inhibitor of TRAP, regulated by T-BOX (trp) sequence RtpA. | 0.815 |
clpE | dnaJ | BL03640 | BL02098 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.851 |
clpE | dnaK | BL03640 | BL02097 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.980 |
clpE | groEL | BL03640 | BL03283 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (chaperonin); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.796 |
clpE | groES | BL03640 | BL03284 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Class I heat-shock protein (chaperonin); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.825 |
clpE | grpE | BL03640 | BL02095 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] | 0.871 |
clpE | hrcA | BL03640 | BL02094 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.648 |
clpE | htpG | BL03640 | BL00247 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Class III heat-shock protein (molecular chaperone); Molecular chaperone. Has ATPase activity. | 0.805 |
clpE | rtpA | BL03640 | BL05022 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Inhibitor of TRAP, regulated by T-BOX (trp) sequence RtpA. | 0.815 |
dnaJ | clpC | BL02098 | BL03261 | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.867 |
dnaJ | clpE | BL02098 | BL03640 | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.851 |
dnaJ | dnaK | BL02098 | BL02097 | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | Class I heat-shock protein (molecular chaperone); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.999 |
dnaJ | groEL | BL02098 | BL03283 | Heat-shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | Class I heat-shock protein (chaperonin); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.941 |