| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BL02225 | mecB | BL02225 | BL02227 | FAD-dependent pyridine nucleotide-disulphide oxidoreductase. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.548 |
| BL02228 | mecB | BL02228 | BL02227 | Putative hydrolase. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.564 |
| blaI | mecB | BL01789 | BL02227 | Putative beta-lactamase repressor protein. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.548 |
| clpC | clpP | BL03261 | BL03605 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | 0.980 |
| clpC | comK | BL03261 | BL01090 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.819 |
| clpC | mcsB | BL03261 | BL03260 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. | 0.999 |
| clpC | mecB | BL03261 | BL02227 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.924 |
| clpE | clpP | BL03640 | BL03605 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | 0.976 |
| clpE | comK | BL03640 | BL01090 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.417 |
| clpE | mcsB | BL03640 | BL03260 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. | 0.915 |
| clpE | mecB | BL03640 | BL02227 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.842 |
| clpP | clpC | BL03605 | BL03261 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.980 |
| clpP | clpE | BL03605 | BL03640 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.976 |
| clpP | mcsB | BL03605 | BL03260 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. | 0.796 |
| clpP | mecB | BL03605 | BL02227 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.598 |
| comK | clpC | BL01090 | BL03261 | Competence transcription factor ComK. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.819 |
| comK | clpE | BL01090 | BL03640 | Competence transcription factor ComK. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.417 |
| comK | mecB | BL01090 | BL02227 | Competence transcription factor ComK. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.535 |
| mcsB | clpC | BL03260 | BL03261 | McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.999 |
| mcsB | clpE | BL03260 | BL03640 | McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.915 |
