| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BL02124 | pabA | BL02124 | BL00859 | Anthranilate phosphoribosyltransferase. | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | 0.955 |
| BL02124 | pabB | BL02124 | BL00858 | Anthranilate phosphoribosyltransferase. | Para-aminobenzoate synthase (subunit A). | 0.970 |
| BL02124 | trpA | BL02124 | BL02770 | Anthranilate phosphoribosyltransferase. | Tryptophan synthase (alpha subunit); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.954 |
| BL02124 | trpB | BL02124 | BL02771 | Anthranilate phosphoribosyltransferase. | Tryptophan synthase (beta subunit); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.974 |
| BL02124 | trpC | BL02124 | BL02773 | Anthranilate phosphoribosyltransferase. | Indol-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.980 |
| BL02124 | trpD | BL02124 | BL02774 | Anthranilate phosphoribosyltransferase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.928 |
| BL02124 | trpE | BL02124 | BL02775 | Anthranilate phosphoribosyltransferase. | Anthranilate synthase; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. | 0.998 |
| BL02124 | trpF | BL02124 | BL02772 | Anthranilate phosphoribosyltransferase. | Phosphoribosyl anthranilate isomerase; Belongs to the TrpF family. | 0.995 |
| glyA | ilvA | BL03991 | BL03302 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.929 |
| glyA | trpA | BL03991 | BL02770 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase (alpha subunit); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.964 |
| glyA | trpB | BL03991 | BL02771 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase (beta subunit); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.919 |
| ilvA | glyA | BL03302 | BL03991 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.929 |
| ilvA | trpA | BL03302 | BL02770 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase (alpha subunit); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.914 |
| ilvA | trpB | BL03302 | BL02771 | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase (beta subunit); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.938 |
| pabA | BL02124 | BL00859 | BL02124 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Anthranilate phosphoribosyltransferase. | 0.955 |
| pabA | pabB | BL00859 | BL00858 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Para-aminobenzoate synthase (subunit A). | 0.999 |
| pabA | trpA | BL00859 | BL02770 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Tryptophan synthase (alpha subunit); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.989 |
| pabA | trpB | BL00859 | BL02771 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Tryptophan synthase (beta subunit); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.984 |
| pabA | trpC | BL00859 | BL02773 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Indol-3-glycerol phosphate synthase; Belongs to the TrpC family. | 0.998 |
| pabA | trpD | BL00859 | BL02774 | Para-aminobenzoate synthase glutamine amidotransferase (subunit B) and anthranilate synthase (subunit II). | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.998 |
