| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bdbC | mecA | BL03005 | BL03330 | Thiol-disulfide oxidoreductase; Required for disulfide bond formation in some proteins. Belongs to the DsbB family. BdbC subfamily. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.693 |
| clpC | clpP | BL03261 | BL03605 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | 0.980 |
| clpC | comK | BL03261 | BL01090 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.819 |
| clpC | mecA | BL03261 | BL03330 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.989 |
| clpE | clpP | BL03640 | BL03605 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | 0.976 |
| clpE | comK | BL03640 | BL01090 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.417 |
| clpE | mecA | BL03640 | BL03330 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.923 |
| clpP | clpC | BL03605 | BL03261 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.980 |
| clpP | clpE | BL03605 | BL03640 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.976 |
| clpP | mecA | BL03605 | BL03330 | ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. ClpXP1 is involved in the complete degradation of the Site-2 clipped anti-sigma-W factor RsiW. This results in the release of SigW and the transcription activation of the genes under the control of the sigma-W factor (By similarity); Belongs to the peptidase S14 family. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.832 |
| comK | clpC | BL01090 | BL03261 | Competence transcription factor ComK. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.819 |
| comK | clpE | BL01090 | BL03640 | Competence transcription factor ComK. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.417 |
| comK | mecA | BL01090 | BL03330 | Competence transcription factor ComK. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.916 |
| comK | yjbF | BL01090 | BL03336 | Competence transcription factor ComK. | Conserved protein YjbF. | 0.589 |
| comK | yjbH | BL01090 | BL03343 | Competence transcription factor ComK. | Conserved protein YjbH; Belongs to the UPF0413 family. | 0.689 |
| comK | ytkD | BL01090 | BL03288 | Competence transcription factor ComK. | Putative hydrolase YtkD; Belongs to the Nudix hydrolase family. | 0.716 |
| comK | ytpQ | BL01090 | BL00047 | Competence transcription factor ComK. | Conserved protein YtpQ; Belongs to the UPF0354 family. | 0.760 |
| mecA | bdbC | BL03330 | BL03005 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Thiol-disulfide oxidoreductase; Required for disulfide bond formation in some proteins. Belongs to the DsbB family. BdbC subfamily. | 0.693 |
| mecA | clpC | BL03330 | BL03261 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.989 |
| mecA | clpE | BL03330 | BL03640 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.923 |
