| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| blaI | mecA | BL01789 | BL03330 | Putative beta-lactamase repressor protein. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.610 |
| clpC | comK | BL03261 | BL01090 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.507 |
| clpC | mecA | BL03261 | BL03330 | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.966 |
| clpE | comK | BL03640 | BL01090 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Competence transcription factor ComK. | 0.402 |
| clpE | mecA | BL03640 | BL03330 | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.877 |
| comK | clpC | BL01090 | BL03261 | Competence transcription factor ComK. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.507 |
| comK | clpE | BL01090 | BL03640 | Competence transcription factor ComK. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.402 |
| comK | mecA | BL01090 | BL03330 | Competence transcription factor ComK. | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | 0.775 |
| comK | yjbH | BL01090 | BL03343 | Competence transcription factor ComK. | Conserved protein YjbH; Belongs to the UPF0413 family. | 0.689 |
| comK | ytkD | BL01090 | BL03288 | Competence transcription factor ComK. | Putative hydrolase YtkD; Belongs to the Nudix hydrolase family. | 0.716 |
| comK | ytpQ | BL01090 | BL00047 | Competence transcription factor ComK. | Conserved protein YtpQ; Belongs to the UPF0354 family. | 0.760 |
| mecA | blaI | BL03330 | BL01789 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Putative beta-lactamase repressor protein. | 0.610 |
| mecA | clpC | BL03330 | BL03261 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Class III stress response-related ATPase; Belongs to the ClpA/ClpB family. | 0.966 |
| mecA | clpE | BL03330 | BL03640 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family. | 0.877 |
| mecA | comK | BL03330 | BL01090 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Competence transcription factor ComK. | 0.775 |
| mecA | trxA | BL03330 | BL00326 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Thioredoxin; Belongs to the thioredoxin family. | 0.608 |
| mecA | yabA | BL03330 | BL00538 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | DnaA and DnaN interacting protein containing domain DUF972- YabA; Involved in initiation control of chromosome replication. Belongs to the YabA family. | 0.621 |
| mecA | yjbH | BL03330 | BL03343 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Conserved protein YjbH; Belongs to the UPF0413 family. | 0.816 |
| mecA | ytkD | BL03330 | BL03288 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Putative hydrolase YtkD; Belongs to the Nudix hydrolase family. | 0.645 |
| mecA | ytpQ | BL03330 | BL00047 | Adaptor protein MecA; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. Acts negatively in the development of competence by binding ComK and recruiting it to the ClpCP protease. When overexpressed, inhibits sporulation. Also involved in Spx degradation by ClpC. | Conserved protein YtpQ; Belongs to the UPF0354 family. | 0.624 |