| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | ywkE | BL03991 | BL03979 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.662 |
| glyA | ywlC | BL03991 | BL03986 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.819 |
| glyA | ywlE | BL03991 | BL03988 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Low molecular weight phosphotyrosine protein phosphatase. | 0.782 |
| glyA | ywlF | BL03991 | BL03989 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Ribose/galactose isomerase. | 0.971 |
| glyA | ywlG | BL03991 | BL03990 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Conserved protein YwlG; Belongs to the UPF0340 family. | 0.508 |
| ywkE | glyA | BL03979 | BL03991 | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.662 |
| ywkE | ywlC | BL03979 | BL03986 | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.848 |
| ywkE | ywlF | BL03979 | BL03989 | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | Ribose/galactose isomerase. | 0.508 |
| ywkE | ywlG | BL03979 | BL03990 | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | Conserved protein YwlG; Belongs to the UPF0340 family. | 0.691 |
| ywlC | glyA | BL03986 | BL03991 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.819 |
| ywlC | ywkE | BL03986 | BL03979 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | YwkE; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. | 0.848 |
| ywlC | ywlD | BL03986 | BL03987 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | YwlD; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | 0.635 |
| ywlC | ywlE | BL03986 | BL03988 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Low molecular weight phosphotyrosine protein phosphatase. | 0.602 |
| ywlC | ywlF | BL03986 | BL03989 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Ribose/galactose isomerase. | 0.496 |
| ywlC | ywlG | BL03986 | BL03990 | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Conserved protein YwlG; Belongs to the UPF0340 family. | 0.572 |
| ywlD | ywlC | BL03987 | BL03986 | YwlD; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | Conserved protein YwlC; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.635 |
| ywlD | ywlE | BL03987 | BL03988 | YwlD; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | Low molecular weight phosphotyrosine protein phosphatase. | 0.546 |
| ywlD | ywlF | BL03987 | BL03989 | YwlD; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | Ribose/galactose isomerase. | 0.411 |
| ywlD | ywlG | BL03987 | BL03990 | YwlD; Probably functions as a manganese efflux pump. Belongs to the MntP (TC 9.B.29) family. | Conserved protein YwlG; Belongs to the UPF0340 family. | 0.403 |
| ywlE | glyA | BL03988 | BL03991 | Low molecular weight phosphotyrosine protein phosphatase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.782 |