STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
clpP2ATP-dependentprotease proteolytic subunit (class III heat-shock protein); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (190 aa)    
Predicted Functional Partners:
clpX
ATP-dependent Clp protease ATP-binding subunit (class III heat-shock protein); ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 0.982
clpE
ATP-dependent Clp protease-like (class III stress gene) ClpE; Belongs to the ClpA/ClpB family.
  
 
 0.876
clpC
Class III stress response-related ATPase; Belongs to the ClpA/ClpB family.
  
 
 0.872
BL04030
RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-M); Belongs to the sigma-70 factor family. ECF subfamily.
  
    0.841
groEL
Class I heat-shock protein (chaperonin); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.711
yusL
3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase YusL.
    
  0.703
mcsB
McsB; Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
   
  
 0.703
groES
Class I heat-shock protein (chaperonin); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
 
 
 0.699
BL00880
ATP-dependent Clp protease proteolytic subunit (class III heat-shock protein); Belongs to the peptidase S14 family.
  
  
 
0.668
BL03503
ATP-dependent protease proteolytic subunit (class III heat-shock protein); Belongs to the peptidase S14 family.
  
  
 
0.666
Your Current Organism:
Bacillus licheniformis
NCBI taxonomy Id: 279010
Other names: B. licheniformis DSM 13 = ATCC 14580, Bacillus licheniformis ATCC 14580, Bacillus licheniformis ATCC 14580 = DSM 13, Bacillus licheniformis DSM 13, Bacillus licheniformis DSM 13 = ATCC 14580
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