STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoType IV apurinic/apyrimidinic endonuclease; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (297 aa)    
Predicted Functional Partners:
yqfR
DEAD/DEAH box ATP dependent helicase YqfR; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.
 
    0.867
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.817
ung
uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
   
 
 0.626
recJ
RecJ exonuclease.
  
  
 0.621
yfjP
Putative DNA glycosylase; Similar to DNA-3-methyladenine glycosidase II.
    
 
 0.563
gyrB
DNA gyrase (subunit B); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
      
 0.561
yqfQ
Tubulin YqfQ.
       0.516
dinG
ATP-dependent helicase; 3'-5' exonuclease.
  
  
 0.510
yqfO
Conserved hypothetical protein; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
     
 0.480
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 
 0.473
Your Current Organism:
Bacillus licheniformis
NCBI taxonomy Id: 279010
Other names: B. licheniformis DSM 13 = ATCC 14580, Bacillus licheniformis ATCC 14580, Bacillus licheniformis ATCC 14580 = DSM 13, Bacillus licheniformis DSM 13, Bacillus licheniformis DSM 13 = ATCC 14580
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.