node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LT85_0322 | LT85_1494 | LT85_0322 | LT85_1494 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase. | 0.930 |
LT85_0322 | LT85_2202 | LT85_0322 | LT85_2202 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Malate synthase; Belongs to the malate synthase family. | 0.924 |
LT85_0322 | acsA | LT85_0322 | LT85_3863 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.930 |
LT85_0322 | prpB | LT85_0322 | LT85_3289 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.825 |
LT85_0322 | sucC | LT85_0322 | LT85_4347 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.819 |
LT85_0322 | sucD | LT85_0322 | LT85_4346 | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.836 |
LT85_1494 | LT85_0322 | LT85_1494 | LT85_0322 | Acetyl-coenzyme A synthetase. | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.930 |
LT85_1494 | LT85_2202 | LT85_1494 | LT85_2202 | Acetyl-coenzyme A synthetase. | Malate synthase; Belongs to the malate synthase family. | 0.950 |
LT85_1494 | LT85_3288 | LT85_1494 | LT85_3288 | Acetyl-coenzyme A synthetase. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.947 |
LT85_1494 | acsA | LT85_1494 | LT85_3863 | Acetyl-coenzyme A synthetase. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.921 |
LT85_1494 | prpB | LT85_1494 | LT85_3289 | Acetyl-coenzyme A synthetase. | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.877 |
LT85_1494 | sucC | LT85_1494 | LT85_4347 | Acetyl-coenzyme A synthetase. | Succinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.850 |
LT85_1494 | sucD | LT85_1494 | LT85_4346 | Acetyl-coenzyme A synthetase. | Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.849 |
LT85_2202 | LT85_0322 | LT85_2202 | LT85_0322 | Malate synthase; Belongs to the malate synthase family. | 3-ketoacyl-CoA thiolase; Belongs to the thiolase-like superfamily. Thiolase family. | 0.924 |
LT85_2202 | LT85_1494 | LT85_2202 | LT85_1494 | Malate synthase; Belongs to the malate synthase family. | Acetyl-coenzyme A synthetase. | 0.950 |
LT85_2202 | LT85_3288 | LT85_2202 | LT85_3288 | Malate synthase; Belongs to the malate synthase family. | 2-methylcitrate synthase; Belongs to the citrate synthase family. | 0.501 |
LT85_2202 | acsA | LT85_2202 | LT85_3863 | Malate synthase; Belongs to the malate synthase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.950 |
LT85_2202 | prpB | LT85_2202 | LT85_3289 | Malate synthase; Belongs to the malate synthase family. | Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.894 |
LT85_2202 | sucC | LT85_2202 | LT85_4347 | Malate synthase; Belongs to the malate synthase family. | Succinyl-CoA ligase [ADP-forming] beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.828 |
LT85_2202 | sucD | LT85_2202 | LT85_4346 | Malate synthase; Belongs to the malate synthase family. | Succinyl-CoA ligase [ADP-forming] alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.864 |