Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (766 aa)    
Predicted Functional Partners:
metH
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.966
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.957
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.951
metC
Cystathionine beta-lyase.
  
 
 0.932
metC-2
Cystathionine beta-lyase.
  
 
 0.932
metC-3
Cystathionine beta-lyase.
  
 
 0.932
metG
methionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
    
 0.924
AMP04380.1
CBS domain protein.
  
 
 0.923
AMP04003.1
O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein.
  
 
 0.917
AMP04805.1
Aminotransferase class-V family protein.
  
 
 0.917
Your Current Organism:
Collimonas pratensis
NCBI taxonomy Id: 279113
Other names: C. pratensis, CCUG 54728, Collimonas group D, Collimonas pratensis Hoppener-Ogawa et al. 2008, Collimonas sp. CTO 113, Collimonas sp. CTO 291, Collimonas sp. CTO 90, Collimonas sp. CTO 91, Collimonas sp. CTO 94, Collimonas sp. Ter113, Collimonas sp. Ter118, Collimonas sp. Ter227, Collimonas sp. Ter291, Collimonas sp. Ter90, Collimonas sp. Ter91, Collimonas sp. Ter94, LMG 23965, LMG:23965, strain Ter91
Server load: low (14%) [HD]