STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
glnDUTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (912 aa)    
Predicted Functional Partners:
Saro_1109
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.970
Saro_3154
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.802
Saro_0683
Protein of unknown function DUF179; Belongs to the UPF0301 (AlgH) family.
 
     0.678
Saro_3176
Glutamate synthase (NADH) large subunit.
     
 0.667
Saro_0693
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 
 0.655
Saro_0681
AMP-dependent synthetase and ligase.
       0.581
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase.
      
 0.575
bamA
Surface antigen (D15); Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
 
    0.485
Saro_1108
L-glutamine synthetase.
 
   
 0.477
Saro_0679
Protein of unknown function DUF185.
       0.451
Your Current Organism:
Novosphingobium aromaticivorans
NCBI taxonomy Id: 279238
Other names: N. aromaticivorans DSM 12444, Novosphingobium aromaticivorans DSM 12444, Novosphingobium aromaticivorans str. DSM 12444, Novosphingobium aromaticivorans strain DSM 12444
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