Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pdhAPyruvate dehydrogenase (lipoamide); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (381 aa)    
Predicted Functional Partners:
Saro_1909
Transketolase, central region; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 0.999
Saro_1946
Dihydrolipoamide acetyltransferase, long form; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 0.995
Saro_1975
Branched-chain alpha-keto acid dehydrogenase E1 component.
 0.995
Saro_1945
Dihydrolipoamide dehydrogenase.
 
 0.989
Saro_1178
Dihydrolipoamide dehydrogenase.
 
 0.971
Saro_3291
Allosteric NADP-dependent malic enzyme.
  
 
 0.956
Saro_1757
Pyruvate flavodoxin/ferredoxin oxidoreductase-like protein.
    
 0.935
Saro_0432
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.913
Saro_2110
Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.
    
 0.910
Saro_0816
D-lactate dehydrogenase (cytochrome).
    
 0.908
Your Current Organism:
Novosphingobium aromaticivorans
NCBI taxonomy Id: 279238
Other names: N. aromaticivorans DSM 12444, Novosphingobium aromaticivorans DSM 12444, Novosphingobium aromaticivorans str. DSM 12444, Novosphingobium aromaticivorans strain DSM 12444
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