node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDA59032.1 | hslU | SAMN03080617_01157 | SAMN03080617_00702 | Preprotein translocase subunit YajC. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.598 |
SDA59032.1 | hslV | SAMN03080617_01157 | SAMN03080617_01799 | Preprotein translocase subunit YajC. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.478 |
SDA61218.1 | SDA93426.1 | SAMN03080617_01320 | SAMN03080617_03725 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Co-chaperonin GroES (HSP10). | 0.618 |
SDA61218.1 | dnaJ | SAMN03080617_01320 | SAMN03080617_01934 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.843 |
SDA61218.1 | groL | SAMN03080617_01320 | SAMN03080617_02238 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.853 |
SDA61218.1 | groS | SAMN03080617_01320 | SAMN03080617_02237 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.618 |
SDA61218.1 | grpE | SAMN03080617_01320 | SAMN03080617_01933 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.707 |
SDA61218.1 | hslU | SAMN03080617_01320 | SAMN03080617_00702 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.725 |
SDA61218.1 | hslV | SAMN03080617_01320 | SAMN03080617_01799 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.739 |
SDA61218.1 | lon | SAMN03080617_01320 | SAMN03080617_00703 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.699 |
SDA80112.1 | SDA93426.1 | SAMN03080617_02424 | SAMN03080617_03725 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | Co-chaperonin GroES (HSP10). | 0.618 |
SDA80112.1 | dnaJ | SAMN03080617_02424 | SAMN03080617_01934 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] | 0.843 |
SDA80112.1 | groL | SAMN03080617_02424 | SAMN03080617_02238 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.855 |
SDA80112.1 | groS | SAMN03080617_02424 | SAMN03080617_02237 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.645 |
SDA80112.1 | grpE | SAMN03080617_02424 | SAMN03080617_01933 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.707 |
SDA80112.1 | hslU | SAMN03080617_02424 | SAMN03080617_00702 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | ATP-dependent HslUV protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.725 |
SDA80112.1 | hslV | SAMN03080617_02424 | SAMN03080617_01799 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | ATP-dependent HslUV protease, peptidase subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.739 |
SDA80112.1 | lon | SAMN03080617_02424 | SAMN03080617_00703 | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | ATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.699 |
SDA93426.1 | SDA61218.1 | SAMN03080617_03725 | SAMN03080617_01320 | Co-chaperonin GroES (HSP10). | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | 0.618 |
SDA93426.1 | SDA80112.1 | SAMN03080617_03725 | SAMN03080617_02424 | Co-chaperonin GroES (HSP10). | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.618 |