STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (462 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.999
hemL
Glutamate-1-semialdehyde aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.997
GU90_05885
uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.990
GU90_05880
Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family.
 
  
 0.980
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
     
 0.969
GU90_09305
uroporphyrin-III C-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.942
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.877
rex
DNA-binding protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.856
GU90_01630
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
 
   
 0.761
GU90_05830
Cytochrome C biogenesis protein ResC; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.699
Your Current Organism:
Saccharopolyspora rectivirgula
NCBI taxonomy Id: 28042
Other names: ATCC 33515, DSM 43747, Faenia rectivirgula, IFO 12464, INMI 683, JCM 3057, Micropolyspora faeni, Micropolyspora rectivirgula, NBRC 12464, NRRL B-16280, S. rectivirgula, Thermopolyspora polyspora, Thermopolyspora rectivirgula, VKM Ac-810
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.