STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (965 aa)    
Predicted Functional Partners:
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine.
 0.999
GU90_10325
Sarcosine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family.
 0.998
gcvH
Hypothetical protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 0.998
gcvH-2
Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
 0.998
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
 
 
 0.997
GU90_10320
Glycine cleavage system protein T; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GcvT family.
 0.996
GU90_10340
Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.995
kgd
Alpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.989
purD
Phosphoribosylamine--glycine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GARS family.
   
  
 0.973
GU90_07560
Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.972
Your Current Organism:
Saccharopolyspora rectivirgula
NCBI taxonomy Id: 28042
Other names: ATCC 33515, DSM 43747, Faenia rectivirgula, IFO 12464, INMI 683, JCM 3057, Micropolyspora faeni, Micropolyspora rectivirgula, NBRC 12464, NRRL B-16280, S. rectivirgula, Thermopolyspora polyspora, Thermopolyspora rectivirgula, VKM Ac-810
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.