| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ORV09616.1 | ORV12614.1 | AWB95_17505 | AWB95_11860 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.971 |
| ORV09616.1 | ORV13625.1 | AWB95_17505 | AWB95_11295 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.997 |
| ORV09616.1 | ORV14121.1 | AWB95_17505 | AWB95_10155 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homocysteine S-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.902 |
| ORV09616.1 | ORV14652.1 | AWB95_17505 | AWB95_08455 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.916 |
| ORV09616.1 | ORV16484.1 | AWB95_17505 | AWB95_06920 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.957 |
| ORV09616.1 | ORV16512.1 | AWB95_17505 | AWB95_07070 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.943 |
| ORV09616.1 | ilvA | AWB95_17505 | AWB95_02260 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.921 |
| ORV09616.1 | metE | AWB95_17505 | AWB95_22375 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.960 |
| ORV09616.1 | metK | AWB95_17505 | AWB95_07400 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.878 |
| ORV09616.1 | metZ | AWB95_17505 | AWB95_18330 | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.898 |
| ORV12614.1 | ORV09616.1 | AWB95_11860 | AWB95_17505 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.971 |
| ORV12614.1 | ORV13625.1 | AWB95_11860 | AWB95_11295 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.943 |
| ORV12614.1 | ORV14121.1 | AWB95_11860 | AWB95_10155 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homocysteine S-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.924 |
| ORV12614.1 | ORV14652.1 | AWB95_11860 | AWB95_08455 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.955 |
| ORV12614.1 | ORV16484.1 | AWB95_11860 | AWB95_06920 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.907 |
| ORV12614.1 | ORV16512.1 | AWB95_11860 | AWB95_07070 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.967 |
| ORV12614.1 | ilvA | AWB95_11860 | AWB95_02260 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.941 |
| ORV12614.1 | metE | AWB95_11860 | AWB95_22375 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.981 |
| ORV12614.1 | metK | AWB95_11860 | AWB95_07400 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.950 |
| ORV12614.1 | metZ | AWB95_11860 | AWB95_18330 | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.971 |
STRING v12.5 is now available!
