CUQ74393.1 protein (Lachnospira pectinoschiza)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

CUQ74393.1

Sporulation protein%2C YlmC/YmxH family. (84 aa)

Predicted Functional Partners:

CUQ74803.1

0.779

CUQ74465.1

0.703

CUQ77753.1

0.696

sigE

0.680

CUQ75406.1

0.680

spoIIE

0.667

sigF_2

0.650

CUQ74201.1

0.646

spoIIIAE

0.631

spoIVB

0.589

Your Current Organism:

Lachnospira pectinoschiza

NCBI taxonomy Id: 28052
Other names: ATCC 49827, L. pectinoschiza, strain 150-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CUQ74201.1	CUQ74393.1	ERS852451_00292	ERS852451_00495	Stage V sporulation protein AC.	Sporulation protein%2C YlmC/YmxH family.	0.646
CUQ74201.1	CUQ74465.1	ERS852451_00292	ERS852451_00568	Stage V sporulation protein AC.	Signal peptide peptidase SppA%2C 36K type.	0.760
CUQ74201.1	CUQ75406.1	ERS852451_00292	ERS852451_01032	Stage V sporulation protein AC.	Sporulation protein YqfD.	0.764
CUQ74201.1	CUQ77753.1	ERS852451_00292	ERS852451_02197	Stage V sporulation protein AC.	Stage II sporulation protein R.	0.774
CUQ74201.1	sigE	ERS852451_00292	ERS852451_00755	Stage V sporulation protein AC.	Stage II sporulation protein GB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.775
CUQ74201.1	sigF_2	ERS852451_00292	ERS852451_00497	Stage V sporulation protein AC.	Stage II sporulation protein AC; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.774
CUQ74201.1	spoIIE	ERS852451_00292	ERS852451_00054	Stage V sporulation protein AC.	Stage II sporulation protein E.	0.778
CUQ74201.1	spoIIIAE	ERS852451_00292	ERS852451_01162	Stage V sporulation protein AC.	Stage III sporulation protein AE precursor.	0.770
CUQ74201.1	spoIVB	ERS852451_00292	ERS852451_01149	Stage V sporulation protein AC.	SpoIVB peptidase precursor.	0.777
CUQ74393.1	CUQ74201.1	ERS852451_00495	ERS852451_00292	Sporulation protein%2C YlmC/YmxH family.	Stage V sporulation protein AC.	0.646
CUQ74393.1	CUQ74465.1	ERS852451_00495	ERS852451_00568	Sporulation protein%2C YlmC/YmxH family.	Signal peptide peptidase SppA%2C 36K type.	0.703
CUQ74393.1	CUQ74803.1	ERS852451_00495	ERS852451_00754	Sporulation protein%2C YlmC/YmxH family.	sigma-E processing peptidase SpoIIGA.	0.779
CUQ74393.1	CUQ75406.1	ERS852451_00495	ERS852451_01032	Sporulation protein%2C YlmC/YmxH family.	Sporulation protein YqfD.	0.680
CUQ74393.1	CUQ77753.1	ERS852451_00495	ERS852451_02197	Sporulation protein%2C YlmC/YmxH family.	Stage II sporulation protein R.	0.696
CUQ74393.1	sigE	ERS852451_00495	ERS852451_00755	Sporulation protein%2C YlmC/YmxH family.	Stage II sporulation protein GB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.680
CUQ74393.1	sigF_2	ERS852451_00495	ERS852451_00497	Sporulation protein%2C YlmC/YmxH family.	Stage II sporulation protein AC; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.650
CUQ74393.1	spoIIE	ERS852451_00495	ERS852451_00054	Sporulation protein%2C YlmC/YmxH family.	Stage II sporulation protein E.	0.667
CUQ74393.1	spoIIIAE	ERS852451_00495	ERS852451_01162	Sporulation protein%2C YlmC/YmxH family.	Stage III sporulation protein AE precursor.	0.631
CUQ74393.1	spoIVB	ERS852451_00495	ERS852451_01149	Sporulation protein%2C YlmC/YmxH family.	SpoIVB peptidase precursor.	0.589
CUQ74465.1	CUQ74201.1	ERS852451_00568	ERS852451_00292	Signal peptide peptidase SppA%2C 36K type.	Stage V sporulation protein AC.	0.760

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.842

expected number of edges:

10

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008643

Carbohydrate transport

9 of 80

1.69

3.52

1.20e-11

GO:0006810

Transport

11 of 669

0.86

0.92

1.88e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030246

Carbohydrate binding

6 of 31

1.93

3.18

4.73e-08

GO:0015611

ABC-type D-ribose transporter activity

3 of 3

2.64

2.25

6.86e-05

GO:0046872

Metal ion binding

6 of 485

0.73

0.46

0.0229

GO:0043167

Ion binding

9 of 1045

0.57

0.43

0.0039

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

6 of 19

2.14

4.23

5.77e-10

GO:0005886

Plasma membrane

11 of 1011

0.68

0.65

1.58e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1026

Periplasmic binding protein, and Pentose transmembrane transport

10 of 13

2.53

9.39

7.45e-21

CL:1027

Periplasmic binding protein, and Pentose transmembrane transport

7 of 8

2.58

6.71

3.84e-14

CL:1042

Periplasmic binding protein, and Pentose transmembrane transport

3 of 5

2.42

2.19

7.52e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02030

Bacterial chemotaxis

4 of 44

1.6

0.00017

map02010

ABC transporters

11 of 419

1.06

1.42

3.21e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042597

Periplasmic space

6 of 162

1.21

1.18

0.00020

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13407

Periplasmic binding protein domain

6 of 10

2.42

4.89

1.40e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR025997

Periplasmic binding protein

6 of 7

2.57

5.18

7.96e-11

IPR028082

Periplasmic binding protein-like I

6 of 30

1.94

3.22

4.42e-08

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