STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaJ_2Chaperone protein DnaJ. (263 aa)    
Predicted Functional Partners:
dnaK_1
Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.997
dnaK_2
Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.997
htpG
High temperature protein G.
  
 0.995
CUQ77074.1
Cadherin-like beta sandwich domain.
    
 0.957
grpE
HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...]
 
 
 0.950
CUQ78165.1
Uncharacterised protein.
 
     0.945
CUQ74086.1
Uncharacterized membrane protein.
  
 
 0.944
udk
Uridine kinase.
    
 0.939
groL
Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.888
rplO
50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
  
 
 0.862
Your Current Organism:
Lachnospira pectinoschiza
NCBI taxonomy Id: 28052
Other names: ATCC 49827, L. pectinoschiza, strain 150-1
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