mlaE protein (Legionella anisa) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

mlaE

ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)

Predicted Functional Partners:

OQW27622.1

0.999

mlaD

0.999

OQW27561.1

0.995

OQW29761.1

0.978

OQW27625.1

0.963

OQW29767.1

0.940

OQW27560.1

0.799

lptB

0.777

lptA

0.648

lptC

0.618

Your Current Organism:

Legionella anisa

NCBI taxonomy Id: 28082
Other names: ATCC 35292, ATCC:35292D-5, CCUG 29665, CIP 103870, DSM 17627, JCM 7573, L. anisa, NCTC 11974, strain WA-316-C3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
OQW27560.1	OQW27561.1	A6J39_06915	A6J39_06920	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OQW27560.1	OQW27622.1	A6J39_06915	A6J39_07265	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
OQW27560.1	OQW27625.1	A6J39_06915	A6J39_07280	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.709
OQW27560.1	OQW29761.1	A6J39_06915	A6J39_06925	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
OQW27560.1	OQW29767.1	A6J39_06915	A6J39_07285	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.743
OQW27560.1	lptB	A6J39_06915	A6J39_07240	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.557
OQW27560.1	mlaD	A6J39_06915	A6J39_07275	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Outer membrane lipid asymmetry maintenance protein MlaD; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.989
OQW27560.1	mlaE	A6J39_06915	A6J39_07270	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.799
OQW27561.1	OQW27560.1	A6J39_06920	A6J39_06915	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
OQW27561.1	OQW27622.1	A6J39_06920	A6J39_07265	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.640
OQW27561.1	OQW27625.1	A6J39_06920	A6J39_07280	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.712
OQW27561.1	OQW29761.1	A6J39_06920	A6J39_06925	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
OQW27561.1	OQW29767.1	A6J39_06920	A6J39_07285	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.770
OQW27561.1	mlaD	A6J39_06920	A6J39_07275	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Outer membrane lipid asymmetry maintenance protein MlaD; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.979
OQW27561.1	mlaE	A6J39_06920	A6J39_07270	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.995
OQW27622.1	OQW27560.1	A6J39_07265	A6J39_06915	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
OQW27622.1	OQW27561.1	A6J39_07265	A6J39_06920	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.640
OQW27622.1	OQW27625.1	A6J39_07265	A6J39_07280	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	Signal peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.955
OQW27622.1	OQW29761.1	A6J39_07265	A6J39_06925	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.972
OQW27622.1	OQW29767.1	A6J39_07265	A6J39_07285	Phospholipid ABC transporter ATP-binding protein MlaF; ABC transporter maintaining outer membrane lipid asymmetry; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.946

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

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