STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypFHydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (743 aa)    
Predicted Functional Partners:
hypE
Hydrogenase expression/formation protein HypE.
 
 
 0.997
hypD
Hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
  
 0.975
hypC
Hydrogenase expression/formation protein HypC.
 
 
 0.975
hypB
Hydrogenase expression/formation protein HypB.
 
   
 0.946
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.944
vhtD
Hydrogenase expression/formation protein.
 
   
 0.898
hoxH
Coenzyme F420-reducing hydrogenase, alpha subunit.
 
   
 0.888
hoxY
Sulfhydrogenase subunit delta.
 
  
 0.840
Lbir_0644
Hydrogenase subunit.
     
 0.812
hydG_1
Hydrogenase/sulfur reductase gamma subunit.
       0.782
Your Current Organism:
Legionella birminghamensis
NCBI taxonomy Id: 28083
Other names: ATCC 43702, CCUG 31233, CCUG 31233 A, CIP 103871, DSM 19232, JCM 7559, L. birminghamensis, NCTC 12437
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.