ppiB protein (Legionella birminghamensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Legionella birminghamensis

NCBI taxonomy Id: 28083
Other names: ATCC 43702, CCUG 31233, CCUG 31233 A, CIP 103871, DSM 19232, JCM 7559, L. birminghamensis, NCTC 12437

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lbir_3048	ppiB	Lbir_3048	Lbir_3045	Cytochrome c5.	Peptidyl-prolyl cis-trans isomerase B (cyclophilin-type PPIase family); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.789
Lbir_3048	tgt_2	Lbir_3048	Lbir_3046	Cytochrome c5.	Queuine/archaeosine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribo [...]	0.773
dnaK	htpG	Lbir_1626	Lbir_0675	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	0.995
dnaK	ndk	Lbir_1626	Lbir_2112	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	0.770
dnaK	pksJ	Lbir_1626	Lbir_2992	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Polyketide synthase, type I.	0.869
dnaK	ppiB	Lbir_1626	Lbir_3045	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Peptidyl-prolyl cis-trans isomerase B (cyclophilin-type PPIase family); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.843
dnaK	rplB	Lbir_1626	Lbir_3198	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.883
dnaK	rplN	Lbir_1626	Lbir_3191	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.	0.908
dnaK	yjeA	Lbir_1626	Lbir_2861	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Endo-1,4-beta-xylanase-like protein.	0.455
htpG	dnaK	Lbir_0675	Lbir_1626	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.995
htpG	pksJ	Lbir_0675	Lbir_2992	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	Polyketide synthase, type I.	0.697
htpG	ppiB	Lbir_0675	Lbir_3045	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	Peptidyl-prolyl cis-trans isomerase B (cyclophilin-type PPIase family); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.852
htpG	rplB	Lbir_0675	Lbir_3198	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.761
htpG	rplN	Lbir_0675	Lbir_3191	Class III heat-shock protein HtpG(molecular chaperone); Molecular chaperone. Has ATPase activity.	50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.	0.563
ndk	dnaK	Lbir_2112	Lbir_1626	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.770
ndk	pksJ	Lbir_2112	Lbir_2992	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Polyketide synthase, type I.	0.498
ndk	ppiB	Lbir_2112	Lbir_3045	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	Peptidyl-prolyl cis-trans isomerase B (cyclophilin-type PPIase family); PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.813
ndk	rplB	Lbir_2112	Lbir_3198	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.	0.897
ndk	rplN	Lbir_2112	Lbir_3191	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.	0.828
ndk	rplU	Lbir_2112	Lbir_0794	Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.	50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.854