cls protein (Legionella cherrii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

cls

Cardiolipin synthase. (537 aa)

Predicted Functional Partners:

Lche_0549

0.779

psd

0.613

CorA

0.549

birA

0.512

Lche_2484

0.458

ribD

0.437

gmk

0.435

Lche_0213

0.421

Your Current Organism:

Legionella cherrii

NCBI taxonomy Id: 28084
Other names: ATCC 35252, CCUG 29666, CIP 103842, DSM 19213, L. cherrii, Legionella cherryi, NCTC 11976, strain ORW

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CorA	Lche_0549	Lche_0551	Lche_0549	Magnesium and cobalt transport protein CorA.	Hypothetical protein.	0.486
CorA	cls	Lche_0551	Lche_0550	Magnesium and cobalt transport protein CorA.	Cardiolipin synthase.	0.549
Lche_0213	cls	Lche_0213	Lche_0550	Type III restriction enzyme, res subunit.	Cardiolipin synthase.	0.421
Lche_0549	CorA	Lche_0549	Lche_0551	Hypothetical protein.	Magnesium and cobalt transport protein CorA.	0.486
Lche_0549	Lche_2484	Lche_0549	Lche_2484	Hypothetical protein.	DNA uptake/competence protein ComA.	0.474
Lche_0549	cls	Lche_0549	Lche_0550	Hypothetical protein.	Cardiolipin synthase.	0.779
Lche_2484	Lche_0549	Lche_2484	Lche_0549	DNA uptake/competence protein ComA.	Hypothetical protein.	0.474
Lche_2484	birA	Lche_2484	Lche_2092	DNA uptake/competence protein ComA.	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.584
Lche_2484	cls	Lche_2484	Lche_0550	DNA uptake/competence protein ComA.	Cardiolipin synthase.	0.458
Lche_2484	gmk	Lche_2484	Lche_1063	DNA uptake/competence protein ComA.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.405
Lche_2484	ribD	Lche_2484	Lche_1189	DNA uptake/competence protein ComA.	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.501
birA	Lche_2484	Lche_2092	Lche_2484	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	DNA uptake/competence protein ComA.	0.584
birA	cls	Lche_2092	Lche_0550	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Cardiolipin synthase.	0.512
birA	ribD	Lche_2092	Lche_1189	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.	0.734
cls	CorA	Lche_0550	Lche_0551	Cardiolipin synthase.	Magnesium and cobalt transport protein CorA.	0.549
cls	Lche_0213	Lche_0550	Lche_0213	Cardiolipin synthase.	Type III restriction enzyme, res subunit.	0.421
cls	Lche_0549	Lche_0550	Lche_0549	Cardiolipin synthase.	Hypothetical protein.	0.779
cls	Lche_2484	Lche_0550	Lche_2484	Cardiolipin synthase.	DNA uptake/competence protein ComA.	0.458
cls	birA	Lche_0550	Lche_2092	Cardiolipin synthase.	biotin-[acetylCoA carboxylase] holoenzyme synthetase and biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.	0.512
cls	gmk	Lche_0550	Lche_1063	Cardiolipin synthase.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.435