AlkA protein (Legionella cherrii) - STRING interaction network

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Score

AlkA

DNA-3-methyladenine glycosylase. (303 aa)

Predicted Functional Partners:

Ada

0.833

Lche_0854

0.756

xthA

0.579

exoA

0.579

polA

0.553

recA

0.439

Lche_1230

0.423

nth

0.400

Your Current Organism:

Legionella cherrii

NCBI taxonomy Id: 28084
Other names: ATCC 35252, CCUG 29666, CIP 103842, DSM 19213, L. cherrii, Legionella cherryi, NCTC 11976, strain ORW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ada	AlkA	Lche_2485	Lche_0852	Ada protein (O6-methylguanine-DNA methyltransferase).	DNA-3-methyladenine glycosylase.	0.833
Ada	polA	Lche_2485	Lche_3025	Ada protein (O6-methylguanine-DNA methyltransferase).	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.824
Ada	recA	Lche_2485	Lche_1258	Ada protein (O6-methylguanine-DNA methyltransferase).	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.731
AlkA	Ada	Lche_0852	Lche_2485	DNA-3-methyladenine glycosylase.	Ada protein (O6-methylguanine-DNA methyltransferase).	0.833
AlkA	Lche_0854	Lche_0852	Lche_0854	DNA-3-methyladenine glycosylase.	Hypothetical protein.	0.756
AlkA	Lche_1230	Lche_0852	Lche_1230	DNA-3-methyladenine glycosylase.	Putative Acetyltransferase, GNAT family.	0.423
AlkA	exoA	Lche_0852	Lche_2467	DNA-3-methyladenine glycosylase.	Exodeoxyribonuclease.	0.579
AlkA	nth	Lche_0852	Lche_2779	DNA-3-methyladenine glycosylase.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.400
AlkA	polA	Lche_0852	Lche_3025	DNA-3-methyladenine glycosylase.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.553
AlkA	recA	Lche_0852	Lche_1258	DNA-3-methyladenine glycosylase.	Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.439
AlkA	xthA	Lche_0852	Lche_2466	DNA-3-methyladenine glycosylase.	Exodeoxyribonuclease III.	0.579
Lche_0854	AlkA	Lche_0854	Lche_0852	Hypothetical protein.	DNA-3-methyladenine glycosylase.	0.756
Lche_1230	AlkA	Lche_1230	Lche_0852	Putative Acetyltransferase, GNAT family.	DNA-3-methyladenine glycosylase.	0.423
exoA	AlkA	Lche_2467	Lche_0852	Exodeoxyribonuclease.	DNA-3-methyladenine glycosylase.	0.579
exoA	nth	Lche_2467	Lche_2779	Exodeoxyribonuclease.	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	0.981
exoA	polA	Lche_2467	Lche_3025	Exodeoxyribonuclease.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.734
exoA	xthA	Lche_2467	Lche_2466	Exodeoxyribonuclease.	Exodeoxyribonuclease III.	0.987
nth	AlkA	Lche_2779	Lche_0852	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	DNA-3-methyladenine glycosylase.	0.400
nth	exoA	Lche_2779	Lche_2467	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	Exodeoxyribonuclease.	0.981
nth	polA	Lche_2779	Lche_3025	Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.783