mutY protein (Legionella cherrii) - STRING interaction network

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Score

mutY

A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (358 aa)

Predicted Functional Partners:

dnaN

0.901

mutM

0.860

exoA

0.833

xthA

0.811

mutL

0.659

polA

0.659

Lche_0994

0.655

Lche_0996

0.647

Lche_0997

0.640

Ada

0.637

Your Current Organism:

Legionella cherrii

NCBI taxonomy Id: 28084
Other names: ATCC 35252, CCUG 29666, CIP 103842, DSM 19213, L. cherrii, Legionella cherryi, NCTC 11976, strain ORW

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ada	mutM	Lche_2485	Lche_0462	Ada protein (O6-methylguanine-DNA methyltransferase).	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.616
Ada	mutY	Lche_2485	Lche_0995	Ada protein (O6-methylguanine-DNA methyltransferase).	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.637
Ada	polA	Lche_2485	Lche_3025	Ada protein (O6-methylguanine-DNA methyltransferase).	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.824
Lche_0994	mutY	Lche_0994	Lche_0995	Hypothetical protein.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.655
Lche_0996	Lche_0997	Lche_0996	Lche_0997	Hypothetical protein.	Hypothetical protein.	0.818
Lche_0996	mutY	Lche_0996	Lche_0995	Hypothetical protein.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.647
Lche_0997	Lche_0996	Lche_0997	Lche_0996	Hypothetical protein.	Hypothetical protein.	0.818
Lche_0997	mutY	Lche_0997	Lche_0995	Hypothetical protein.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.640
dnaN	exoA	Lche_2908	Lche_2467	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Exodeoxyribonuclease.	0.847
dnaN	mutL	Lche_2908	Lche_0408	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	0.951
dnaN	mutY	Lche_2908	Lche_0995	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.901
dnaN	polA	Lche_2908	Lche_3025	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.993
dnaN	xthA	Lche_2908	Lche_2466	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	Exodeoxyribonuclease III.	0.847
exoA	dnaN	Lche_2467	Lche_2908	Exodeoxyribonuclease.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.847
exoA	mutY	Lche_2467	Lche_0995	Exodeoxyribonuclease.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.833
exoA	polA	Lche_2467	Lche_3025	Exodeoxyribonuclease.	DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.	0.734
exoA	xthA	Lche_2467	Lche_2466	Exodeoxyribonuclease.	Exodeoxyribonuclease III.	0.987
mutL	dnaN	Lche_0408	Lche_2908	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]	0.951
mutL	mutM	Lche_0408	Lche_0462	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.643
mutL	mutY	Lche_0408	Lche_0995	DNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.659