Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hmgAHomogentisate 1,2-dioxygenase. (418 aa)    
Predicted Functional Partners:
lly
4-hydroxyphenylpyruvate dioxygenase.
 
 0.998
Lche_0222
Glutathione S-transferase (maleylacetoacetate isomerase).
 
 
 0.993
phhA
Phenylalanine-4-hydroxylase.
 
  
 0.931
Lche_0221
Fumarylacetoacetate hydrolase.
 
  
 0.815
ruvA
Holliday junction DNA helicase; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
     
 0.723
yebC
YebC.
       0.693
ruvC
Crossover junction endodeoxyribonuclease ruvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
       0.693
nagK
Fumarylpyruvate hydrolase.
  
  
 0.680
Lche_1986
Pterin-4-alpha-carbinolamine dehydratase.
  
  
 0.631
kynU
Kynureninase.
 
  
 0.552
Your Current Organism:
Legionella cherrii
NCBI taxonomy Id: 28084
Other names: ATCC 35252, CCUG 29666, CIP 103842, DSM 19213, L. cherrii, Legionella cherryi, NCTC 11976, strain ORW
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