mutT_1 protein (Legionella cherrii) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

mutT_1

Mutator protein MutT; Belongs to the Nudix hydrolase family. (132 aa)

Predicted Functional Partners:

secA

0.839

yjbN

0.554

recJ

0.550

Lche_1692

0.491

yfdZ

0.434

mutY

0.421

mutM

0.410

Your Current Organism:

Legionella cherrii

NCBI taxonomy Id: 28084
Other names: ATCC 35252, CCUG 29666, CIP 103842, DSM 19213, L. cherrii, Legionella cherryi, NCTC 11976, strain ORW

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lche_1692	mutT_1	Lche_1692	Lche_1686	Hypothetical protein.	Mutator protein MutT; Belongs to the Nudix hydrolase family.	0.491
Lche_1692	recJ	Lche_1692	Lche_1691	Hypothetical protein.	Single-stranded-DNA-specific exonuclease RecJ.	0.838
Lche_1692	secA	Lche_1692	Lche_1687	Hypothetical protein.	Preprotein translocase, secretion protein SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.	0.496
Lche_1692	yfdZ	Lche_1692	Lche_1693	Hypothetical protein.	Aminotransferase, PLP-dependent.	0.838
Lche_1692	yjbN	Lche_1692	Lche_1690	Hypothetical protein.	tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.	0.696
mutM	mutT_1	Lche_0462	Lche_1686	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Mutator protein MutT; Belongs to the Nudix hydrolase family.	0.410
mutM	mutY	Lche_0462	Lche_0995	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.860
mutM	recJ	Lche_0462	Lche_1691	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	Single-stranded-DNA-specific exonuclease RecJ.	0.594
mutT_1	Lche_1692	Lche_1686	Lche_1692	Mutator protein MutT; Belongs to the Nudix hydrolase family.	Hypothetical protein.	0.491
mutT_1	mutM	Lche_1686	Lche_0462	Mutator protein MutT; Belongs to the Nudix hydrolase family.	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.410
mutT_1	mutY	Lche_1686	Lche_0995	Mutator protein MutT; Belongs to the Nudix hydrolase family.	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	0.421
mutT_1	recJ	Lche_1686	Lche_1691	Mutator protein MutT; Belongs to the Nudix hydrolase family.	Single-stranded-DNA-specific exonuclease RecJ.	0.550
mutT_1	secA	Lche_1686	Lche_1687	Mutator protein MutT; Belongs to the Nudix hydrolase family.	Preprotein translocase, secretion protein SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.	0.839
mutT_1	yfdZ	Lche_1686	Lche_1693	Mutator protein MutT; Belongs to the Nudix hydrolase family.	Aminotransferase, PLP-dependent.	0.434
mutT_1	yjbN	Lche_1686	Lche_1690	Mutator protein MutT; Belongs to the Nudix hydrolase family.	tRNA-dihydrouridine synthase A; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family.	0.554
mutY	mutM	Lche_0995	Lche_0462	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	formamidopyrimidine-DNA glycosylase MutM; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.	0.860
mutY	mutT_1	Lche_0995	Lche_1686	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	Mutator protein MutT; Belongs to the Nudix hydrolase family.	0.421
mutY	recJ	Lche_0995	Lche_1691	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	Single-stranded-DNA-specific exonuclease RecJ.	0.583
mutY	secA	Lche_0995	Lche_1687	A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.	Preprotein translocase, secretion protein SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family.	0.596
recJ	Lche_1692	Lche_1691	Lche_1692	Single-stranded-DNA-specific exonuclease RecJ.	Hypothetical protein.	0.838