ytfL protein (Legionella cincinnatiensis) - STRING interaction network

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second shell of interactors

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

ytfL

Metal ion transporter. (438 aa)

Predicted Functional Partners:

guaA

0.828

Lcin_0009

0.764

hpt

0.683

purH

0.681

surE

0.676

yggV

0.630

purA

0.600

Lcin_0010

0.560

yjjG

0.560

guaA_2

0.524

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_0009	Lcin_0010	Lcin_0009	Lcin_0010	Proton transporter.	Hypothetical protein.	0.546
Lcin_0009	ytfL	Lcin_0009	Lcin_0008	Proton transporter.	Metal ion transporter.	0.764
Lcin_0010	Lcin_0009	Lcin_0010	Lcin_0009	Hypothetical protein.	Proton transporter.	0.546
Lcin_0010	ytfL	Lcin_0010	Lcin_0008	Hypothetical protein.	Metal ion transporter.	0.560
guaA	guaA_2	Lcin_2940	Lcin_2388	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Glutamine amidotransferase, class I.	0.506
guaA	hpt	Lcin_2940	Lcin_0249	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Pyrimidine phosphoribosyl transferase.	0.789
guaA	purA	Lcin_2940	Lcin_2808	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.872
guaA	purH	Lcin_2940	Lcin_1948	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Phosphoribosylaminoimidazolecarboxamide formyltransferase and IMP cyclohydrolase (bifunctional).	0.834
guaA	surE	Lcin_2940	Lcin_2484	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.784
guaA	yggV	Lcin_2940	Lcin_3399	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.847
guaA	yjjG	Lcin_2940	Lcin_0255	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Haloacid dehalogenase.	0.684
guaA	ytfL	Lcin_2940	Lcin_0008	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	Metal ion transporter.	0.828
guaA_2	guaA	Lcin_2388	Lcin_2940	Glutamine amidotransferase, class I.	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.506
guaA_2	hpt	Lcin_2388	Lcin_0249	Glutamine amidotransferase, class I.	Pyrimidine phosphoribosyl transferase.	0.471
guaA_2	surE	Lcin_2388	Lcin_2484	Glutamine amidotransferase, class I.	Acid phosphatase SurE (Stationary phase survival protein); Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.	0.467
guaA_2	yggV	Lcin_2388	Lcin_3399	Glutamine amidotransferase, class I.	dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.	0.418
guaA_2	yjjG	Lcin_2388	Lcin_0255	Glutamine amidotransferase, class I.	Haloacid dehalogenase.	0.416
guaA_2	ytfL	Lcin_2388	Lcin_0008	Glutamine amidotransferase, class I.	Metal ion transporter.	0.524
hpt	guaA	Lcin_0249	Lcin_2940	Pyrimidine phosphoribosyl transferase.	GMP synthetase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.	0.789
hpt	guaA_2	Lcin_0249	Lcin_2388	Pyrimidine phosphoribosyl transferase.	Glutamine amidotransferase, class I.	0.471