Lcin_0024 protein (Legionella cincinnatiensis)

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Lcin_0024

NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (394 aa)

Predicted Functional Partners:

mdh

0.898

frmC

0.868

fumC

0.867

sfcA_1

0.857

maeB

0.857

sfcA_2

0.857

capP

0.856

pykA

0.813

Lcin_1271

0.810

pta

0.756

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_0024	Lcin_1271	Lcin_0024	Lcin_1271	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.810
Lcin_0024	capP	Lcin_0024	Lcin_1808	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	0.856
Lcin_0024	frmC	Lcin_0024	Lcin_2277	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde.	0.868
Lcin_0024	fumC	Lcin_0024	Lcin_0967	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.867
Lcin_0024	maeB	Lcin_0024	Lcin_2356	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	NADP-dependent malic enzyme.	0.857
Lcin_0024	mdh	Lcin_0024	Lcin_1214	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.898
Lcin_0024	pta	Lcin_0024	Lcin_1582	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Phosphate acetyl/butaryl transferase.	0.756
Lcin_0024	pykA	Lcin_0024	Lcin_0108	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.813
Lcin_0024	sfcA_1	Lcin_0024	Lcin_1687	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate dehydrogenase.	0.857
Lcin_0024	sfcA_2	Lcin_0024	Lcin_2482	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate oxidoreductase.	0.857
Lcin_1271	Lcin_0024	Lcin_1271	Lcin_0024	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.810
Lcin_1271	fumC	Lcin_1271	Lcin_0967	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.806
Lcin_1271	maeB	Lcin_1271	Lcin_2356	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NADP-dependent malic enzyme.	0.884
Lcin_1271	mdh	Lcin_1271	Lcin_1214	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.969
Lcin_1271	pta	Lcin_1271	Lcin_1582	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Phosphate acetyl/butaryl transferase.	0.988
Lcin_1271	pykA	Lcin_1271	Lcin_0108	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.927
Lcin_1271	sfcA_1	Lcin_1271	Lcin_1687	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate dehydrogenase.	0.884
Lcin_1271	sfcA_2	Lcin_1271	Lcin_2482	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate oxidoreductase.	0.884
capP	Lcin_0024	Lcin_1808	Lcin_0024	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.856
capP	maeB	Lcin_1808	Lcin_2356	Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.	NADP-dependent malic enzyme.	0.602

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