acsB protein (Legionella cincinnatiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

acsB

acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (626 aa)

Predicted Functional Partners:

fadB

0.932

yfcX

0.923

Hgd

0.911

pta

0.886

Lcin_0503

0.862

mmsA

0.854

prpC

0.838

gltA

0.838

rkpA

0.833

tycC_2

0.833

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hgd	acsB	Lcin_0099	Lcin_0098	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.911
Hgd	fadB	Lcin_0099	Lcin_2852	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.813
Hgd	mmsA	Lcin_0099	Lcin_0100	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.881
Hgd	rkpA	Lcin_0099	Lcin_0960	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Type I polyketide synthase WcbR.	0.440
Hgd	yfcX	Lcin_0099	Lcin_3310	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.813
Lcin_0503	acsB	Lcin_0503	Lcin_0098	Saframycin Mx1 synthetase B.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.862
Lcin_0503	fadB	Lcin_0503	Lcin_2852	Saframycin Mx1 synthetase B.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.945
Lcin_0503	gltA	Lcin_0503	Lcin_3297	Saframycin Mx1 synthetase B.	Citrate synthase; Belongs to the citrate synthase family.	0.791
Lcin_0503	mmsA	Lcin_0503	Lcin_0100	Saframycin Mx1 synthetase B.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.691
Lcin_0503	prpC	Lcin_0503	Lcin_0286	Saframycin Mx1 synthetase B.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.791
Lcin_0503	pta	Lcin_0503	Lcin_1582	Saframycin Mx1 synthetase B.	Phosphate acetyl/butaryl transferase.	0.829
Lcin_0503	rkpA	Lcin_0503	Lcin_0960	Saframycin Mx1 synthetase B.	Type I polyketide synthase WcbR.	0.988
Lcin_0503	tycC_2	Lcin_0503	Lcin_1179	Saframycin Mx1 synthetase B.	Non-ribosomal peptide synthase.	0.999
Lcin_0503	yfcX	Lcin_0503	Lcin_3310	Saframycin Mx1 synthetase B.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.945
acsB	Hgd	Lcin_0098	Lcin_0099	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.911
acsB	Lcin_0503	Lcin_0098	Lcin_0503	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Saframycin Mx1 synthetase B.	0.862
acsB	fadB	Lcin_0098	Lcin_2852	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.932
acsB	gltA	Lcin_0098	Lcin_3297	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Citrate synthase; Belongs to the citrate synthase family.	0.838
acsB	mmsA	Lcin_0098	Lcin_0100	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.854
acsB	prpC	Lcin_0098	Lcin_0286	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.838

page 1 of 5

Server load: low (26%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About