Hgd protein (Legionella cincinnatiensis) - STRING interaction network

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Score

Hgd

3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (298 aa)

Predicted Functional Partners:

echA8_2

0.996

acsB

0.976

mmsA

0.963

ywdH

0.865

prpC

0.856

odp

0.853

echA8_1

0.825

fadB

0.772

yfcX

0.772

argD

0.695

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hgd	acsB	Lcin_0099	Lcin_0098	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.976
Hgd	argD	Lcin_0099	Lcin_0994	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.695
Hgd	echA8_1	Lcin_0099	Lcin_1538	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.825
Hgd	echA8_2	Lcin_0099	Lcin_1409	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.996
Hgd	fadB	Lcin_0099	Lcin_2852	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.772
Hgd	mmsA	Lcin_0099	Lcin_0100	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.963
Hgd	odp	Lcin_0099	Lcin_0324	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Branched-chain alpha-keto acid dehydrogenase subunit E2.	0.853
Hgd	prpC	Lcin_0099	Lcin_0286	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.856
Hgd	yfcX	Lcin_0099	Lcin_3310	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.772
Hgd	ywdH	Lcin_0099	Lcin_2286	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.865
acsB	Hgd	Lcin_0098	Lcin_0099	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.976
acsB	echA8_1	Lcin_0098	Lcin_1538	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	enoyl-CoA hydratase.	0.602
acsB	echA8_2	Lcin_0098	Lcin_1409	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	enoyl-CoA hydratase.	0.487
acsB	fadB	Lcin_0098	Lcin_2852	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.746
acsB	mmsA	Lcin_0098	Lcin_0100	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.954
acsB	odp	Lcin_0098	Lcin_0324	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Branched-chain alpha-keto acid dehydrogenase subunit E2.	0.851
acsB	prpC	Lcin_0098	Lcin_0286	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.892
acsB	yfcX	Lcin_0098	Lcin_3310	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.714
acsB	ywdH	Lcin_0098	Lcin_2286	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	0.861
argD	Hgd	Lcin_0994	Lcin_0099	Ornithine/acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.695