Hgd protein (Legionella cincinnatiensis) - STRING interaction network

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Score

Hgd

3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family. (298 aa)

Predicted Functional Partners:

echA8_2

0.992

acsB

0.911

mmsA

0.881

fadB

0.813

yfcX

0.813

echA8_1

0.808

pheA_2

0.695

garR

0.691

paaF

0.690

mccA

0.640

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Hgd	acsB	Lcin_0099	Lcin_0098	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	0.911
Hgd	echA8_1	Lcin_0099	Lcin_1538	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.808
Hgd	echA8_2	Lcin_0099	Lcin_1409	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.992
Hgd	fadB	Lcin_0099	Lcin_2852	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.813
Hgd	garR	Lcin_0099	Lcin_0263	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	3-hydroxyisobutyrate dehydrogenase.	0.691
Hgd	mccA	Lcin_0099	Lcin_1539	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Acyl CoA carboxylase subunit alpha.	0.640
Hgd	mmsA	Lcin_0099	Lcin_0100	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.881
Hgd	paaF	Lcin_0099	Lcin_1408	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	enoyl-CoA hydratase.	0.690
Hgd	pheA_2	Lcin_0099	Lcin_2173	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Chorismate mutase.	0.695
Hgd	yfcX	Lcin_0099	Lcin_3310	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.813
acsB	Hgd	Lcin_0098	Lcin_0099	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.911
acsB	echA8_1	Lcin_0098	Lcin_1538	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	enoyl-CoA hydratase.	0.616
acsB	echA8_2	Lcin_0098	Lcin_1409	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	enoyl-CoA hydratase.	0.598
acsB	fadB	Lcin_0098	Lcin_2852	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyacyl CoA dehydrogenase oxidoreductase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.932
acsB	garR	Lcin_0098	Lcin_0263	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	3-hydroxyisobutyrate dehydrogenase.	0.423
acsB	mccA	Lcin_0098	Lcin_1539	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Acyl CoA carboxylase subunit alpha.	0.524
acsB	mmsA	Lcin_0098	Lcin_0100	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Methylmalonate-semialdehyde dehydrogenase [acylating] (MMSDH), oxidoreductase.	0.854
acsB	paaF	Lcin_0098	Lcin_1408	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	enoyl-CoA hydratase.	0.508
acsB	yfcX	Lcin_0098	Lcin_3310	acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.	Enoyl CoA hydratase; In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.	0.923
echA8_1	Hgd	Lcin_1538	Lcin_0099	enoyl-CoA hydratase.	3-hydroxyisobutyrate dehydrogenase; Belongs to the HIBADH-related family.	0.808