thiJ protein (Legionella cincinnatiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

thiJ

4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme. (212 aa)

Predicted Functional Partners:

rpoD

0.781

thiDE

0.713

rpoH

0.554

rpoS

0.554

umuD

0.433

Lcin_0590

0.429

Lcin_0271

0.419

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_0271	thiJ	Lcin_0271	Lcin_0589	Isochorismatase.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.419
Lcin_0590	thiJ	Lcin_0590	Lcin_0589	Transposase IS66 family protein.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.429
rpoD	rpoH	Lcin_1207	Lcin_0685	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.	0.461
rpoD	thiJ	Lcin_1207	Lcin_0589	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.781
rpoD	umuD	Lcin_1207	Lcin_0566	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	Peptidase S24 family protein; Belongs to the peptidase S24 family.	0.496
rpoH	rpoD	Lcin_0685	Lcin_1207	RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.461
rpoH	thiJ	Lcin_0685	Lcin_0589	RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.554
rpoS	thiJ	Lcin_2486	Lcin_0589	RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.554
thiDE	thiJ	Lcin_1435	Lcin_0589	Phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.713
thiJ	Lcin_0271	Lcin_0589	Lcin_0271	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	Isochorismatase.	0.419
thiJ	Lcin_0590	Lcin_0589	Lcin_0590	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	Transposase IS66 family protein.	0.429
thiJ	rpoD	Lcin_0589	Lcin_1207	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.781
thiJ	rpoH	Lcin_0589	Lcin_0685	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	RNA polymerase sigma-32 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes.	0.554
thiJ	rpoS	Lcin_0589	Lcin_2486	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	RNA polymerase sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.	0.554
thiJ	thiDE	Lcin_0589	Lcin_1435	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	Phosphomethylpyrimidine kinase/thiamin-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.	0.713
thiJ	umuD	Lcin_0589	Lcin_0566	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	Peptidase S24 family protein; Belongs to the peptidase S24 family.	0.433
umuD	rpoD	Lcin_0566	Lcin_1207	Peptidase S24 family protein; Belongs to the peptidase S24 family.	RNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.496
umuD	thiJ	Lcin_0566	Lcin_0589	Peptidase S24 family protein; Belongs to the peptidase S24 family.	4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme.	0.433