node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lcin_0885 | folB | Lcin_0885 | Lcin_2308 | 6-pyruvoyl tetrahydropterin synthase. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.665 |
Lcin_0885 | folE | Lcin_0885 | Lcin_0757 | 6-pyruvoyl tetrahydropterin synthase. | GTP cyclohydrolase I. | 0.908 |
Lcin_0885 | folK | Lcin_0885 | Lcin_0295 | 6-pyruvoyl tetrahydropterin synthase. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.721 |
folB | Lcin_0885 | Lcin_2308 | Lcin_0885 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 6-pyruvoyl tetrahydropterin synthase. | 0.665 |
folB | folE | Lcin_2308 | Lcin_0757 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | GTP cyclohydrolase I. | 0.982 |
folB | folK | Lcin_2308 | Lcin_0295 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.986 |
folB | folP | Lcin_2308 | Lcin_0782 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.987 |
folB | ribD | Lcin_2308 | Lcin_2464 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.460 |
folB | yggV | Lcin_2308 | Lcin_3399 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.498 |
folE | Lcin_0885 | Lcin_0757 | Lcin_0885 | GTP cyclohydrolase I. | 6-pyruvoyl tetrahydropterin synthase. | 0.908 |
folE | folB | Lcin_0757 | Lcin_2308 | GTP cyclohydrolase I. | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. | 0.982 |
folE | folK | Lcin_0757 | Lcin_0295 | GTP cyclohydrolase I. | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 0.997 |
folE | folP | Lcin_0757 | Lcin_0782 | GTP cyclohydrolase I. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.993 |
folE | gmr_3 | Lcin_0757 | Lcin_2586 | GTP cyclohydrolase I. | Regulatory protein (GGDEF domain). | 0.689 |
folE | hinT | Lcin_0757 | Lcin_0756 | GTP cyclohydrolase I. | Purine nucleoside phosphoramidase. | 0.787 |
folE | ribA | Lcin_0757 | Lcin_2465 | GTP cyclohydrolase I. | Riboflavin biosynthesis protein RibA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. | 0.760 |
folE | ribD | Lcin_0757 | Lcin_2464 | GTP cyclohydrolase I. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.817 |
folE | ycdT | Lcin_0757 | Lcin_1089 | GTP cyclohydrolase I. | Regulatory protein (GGDEF domain). | 0.687 |
folE | yggV | Lcin_0757 | Lcin_3399 | GTP cyclohydrolase I. | dITP/XTP pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.798 |
folK | Lcin_0885 | Lcin_0295 | Lcin_0885 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. | 6-pyruvoyl tetrahydropterin synthase. | 0.721 |