glmU protein (Legionella cincinnatiensis) - STRING interaction network

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glmU

Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (459 aa)

Predicted Functional Partners:

glmS

0.925

msrA_1

0.894

murA

0.832

prs

0.778

rmlB

0.767

galU

0.760

algC

0.725

rmlA1

0.693

rfbF

0.675

Lcin_2981

0.666

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_2981	algC	Lcin_2981	Lcin_3406	Ribose-phosphate pyrophosphokinase.	Phosphomannomutase.	0.439
Lcin_2981	glmS	Lcin_2981	Lcin_0844	Ribose-phosphate pyrophosphokinase.	Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.480
Lcin_2981	glmU	Lcin_2981	Lcin_0867	Ribose-phosphate pyrophosphokinase.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.666
Lcin_2981	msrA_1	Lcin_2981	Lcin_0781	Ribose-phosphate pyrophosphokinase.	Phosphoglucomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.439
algC	Lcin_2981	Lcin_3406	Lcin_2981	Phosphomannomutase.	Ribose-phosphate pyrophosphokinase.	0.439
algC	galU	Lcin_3406	Lcin_1402	Phosphomannomutase.	Glucose-1-phosphate uridylyltransferase.	0.924
algC	glmS	Lcin_3406	Lcin_0844	Phosphomannomutase.	Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.741
algC	glmU	Lcin_3406	Lcin_0867	Phosphomannomutase.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.725
algC	msrA_1	Lcin_3406	Lcin_0781	Phosphomannomutase.	Phosphoglucomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.664
algC	prs	Lcin_3406	Lcin_0659	Phosphomannomutase.	Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.	0.681
algC	rfbF	Lcin_3406	Lcin_0835	Phosphomannomutase.	Glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase).	0.681
algC	rmlA1	Lcin_3406	Lcin_1729	Phosphomannomutase.	Nucleotidyltransferase.	0.805
algC	rmlB	Lcin_3406	Lcin_1632	Phosphomannomutase.	dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.444
galU	algC	Lcin_1402	Lcin_3406	Glucose-1-phosphate uridylyltransferase.	Phosphomannomutase.	0.924
galU	glmS	Lcin_1402	Lcin_0844	Glucose-1-phosphate uridylyltransferase.	Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.	0.440
galU	glmU	Lcin_1402	Lcin_0867	Glucose-1-phosphate uridylyltransferase.	Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.	0.760
galU	msrA_1	Lcin_1402	Lcin_0781	Glucose-1-phosphate uridylyltransferase.	Phosphoglucomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.806
galU	rfbF	Lcin_1402	Lcin_0835	Glucose-1-phosphate uridylyltransferase.	Glucose-1-phosphate cytidylyltransferase (CDP-glucose pyrophosphorylase).	0.635
galU	rmlA1	Lcin_1402	Lcin_1729	Glucose-1-phosphate uridylyltransferase.	Nucleotidyltransferase.	0.784
galU	rmlB	Lcin_1402	Lcin_1632	Glucose-1-phosphate uridylyltransferase.	dTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.	0.767

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