Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sdhSerine 3-dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)    
Predicted Functional Partners:
lgrD_1
Non-ribosomal peptide synthetase; Belongs to the ATP-dependent AMP-binding enzyme family.
   
  0.903
rkpA
Type I polyketide synthase WcbR.
 
 
 0.869
Lcin_1779
Peptide synthetase, non-ribosomal.
 
 
 0.856
tdh
Threonine(-3-)dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
    
  0.850
kbl
2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
     
  0.848
tycC_2
Non-ribosomal peptide synthase.
  
 
 0.834
Lcin_1849
acyl-CoA synthetase.
  
 
 0.794
pksM
Polyketide synthase.
  
 
 0.723
gcsB
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily.
 
      0.691
Lcin_0503
Saframycin Mx1 synthetase B.
 
 
 0.690
Your Current Organism:
Legionella cincinnatiensis
NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H
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