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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cpxA_2-2Sensor histidine kinase. (417 aa)    
Predicted Functional Partners:
evgS_2
Sensor histidine kinase.
  
0.998
arcB_1
Sensory histidine-kinase / response regulator.
 
 0.985
ompR
DNA-binding response regulator in two-component regulatory system with EnvZ.
 
 0.978
arcB_4
Sensory box histidine kinase/response regulator.
 
0.977
luxQ
Sensor histidine kinase.
 
0.962
cyaB
Guanylate/adenylate cyclase.
 
 0.950
evgS_1
Sensory box histidine kinase/response regulator.
 
0.947
cph1
Two-component sensor histidine kinase.
 
 
 0.923
gmr_2
Sensory box/GGDEF domain protein.
   
 0.921
letS
Legionella transmission sensor LetS.
 
0.910
Your Current Organism:
Legionella cincinnatiensis
NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H
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