maeB protein (Legionella cincinnatiensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

maeB

NADP-dependent malic enzyme. (407 aa)

Predicted Functional Partners:

fumC

0.940

prpC

0.929

gltA

0.929

pykA

0.889

mdh

0.884

Lcin_1271

0.884

budB

0.878

ppsA

0.866

porB

0.859

Lcin_0024

0.857

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_0024	Lcin_1271	Lcin_0024	Lcin_1271	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.810
Lcin_0024	budB	Lcin_0024	Lcin_1642	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Acetolactate synthase; Belongs to the TPP enzyme family.	0.593
Lcin_0024	fumC	Lcin_0024	Lcin_0967	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.867
Lcin_0024	maeB	Lcin_0024	Lcin_2356	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	NADP-dependent malic enzyme.	0.857
Lcin_0024	mdh	Lcin_0024	Lcin_1214	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.898
Lcin_0024	porB	Lcin_0024	Lcin_1272	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	2-oxoglutarate ferredoxin oxidoreductase subunit beta.	0.609
Lcin_0024	ppsA	Lcin_0024	Lcin_3103	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.	0.645
Lcin_0024	pykA	Lcin_0024	Lcin_0108	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.813
Lcin_1271	Lcin_0024	Lcin_1271	Lcin_0024	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.810
Lcin_1271	budB	Lcin_1271	Lcin_1642	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Acetolactate synthase; Belongs to the TPP enzyme family.	0.907
Lcin_1271	fumC	Lcin_1271	Lcin_0967	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.806
Lcin_1271	gltA	Lcin_1271	Lcin_3297	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Citrate synthase; Belongs to the citrate synthase family.	0.910
Lcin_1271	maeB	Lcin_1271	Lcin_2356	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	NADP-dependent malic enzyme.	0.884
Lcin_1271	mdh	Lcin_1271	Lcin_1214	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.	0.969
Lcin_1271	porB	Lcin_1271	Lcin_1272	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	2-oxoglutarate ferredoxin oxidoreductase subunit beta.	0.999
Lcin_1271	ppsA	Lcin_1271	Lcin_3103	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.	0.936
Lcin_1271	prpC	Lcin_1271	Lcin_0286	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	2-methylcitrate synthase; Belongs to the citrate synthase family.	0.910
Lcin_1271	pykA	Lcin_1271	Lcin_0108	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	Pyruvate kinase II; Belongs to the pyruvate kinase family.	0.927
budB	Lcin_0024	Lcin_1642	Lcin_0024	Acetolactate synthase; Belongs to the TPP enzyme family.	NAD+-dependent formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.	0.593
budB	Lcin_1271	Lcin_1642	Lcin_1271	Acetolactate synthase; Belongs to the TPP enzyme family.	2-oxoglutarate ferredoxin oxidoreductase subunit alpha.	0.907