sdhL protein (Legionella cincinnatiensis) - STRING interaction network

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Score

sdhL

L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)

Predicted Functional Partners:

glyA

0.921

Lcin_1937

0.876

metB

0.872

trpA

0.863

gloA

0.848

trpB

0.848

pssA

0.848

glyA_2

0.843

budB

0.712

serC

0.670

Your Current Organism:

Legionella cincinnatiensis

NCBI taxonomy Id: 28085
Other names: ATCC 43753, CCUG 31230 A, CIP 103875, DSM 19233, L. cincinnatiensis, NCTC 12438, strain 72-OH-H

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lcin_1937	glyA	Lcin_1937	Lcin_1342	Phosphoserine phosphatase.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.881
Lcin_1937	glyA_2	Lcin_1937	Lcin_1083	Phosphoserine phosphatase.	Serine hydroxymethyltransferase.	0.688
Lcin_1937	metB	Lcin_1937	Lcin_1359	Phosphoserine phosphatase.	Cystathionine beta-lyase.	0.490
Lcin_1937	pssA	Lcin_1937	Lcin_2797	Phosphoserine phosphatase.	CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.849
Lcin_1937	sdhL	Lcin_1937	Lcin_3088	Phosphoserine phosphatase.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.876
Lcin_1937	serC	Lcin_1937	Lcin_3295	Phosphoserine phosphatase.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.840
Lcin_1937	trpA	Lcin_1937	Lcin_2508	Phosphoserine phosphatase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.849
Lcin_1937	trpB	Lcin_1937	Lcin_2507	Phosphoserine phosphatase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.869
budB	sdhL	Lcin_1642	Lcin_3088	Acetolactate synthase; Belongs to the TPP enzyme family.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.712
gloA	sdhL	Lcin_1064	Lcin_3088	Lactoylglutathione lyase.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.848
gloA	trpA	Lcin_1064	Lcin_2508	Lactoylglutathione lyase.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.848
gloA	trpB	Lcin_1064	Lcin_2507	Lactoylglutathione lyase.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.858
glyA	Lcin_1937	Lcin_1342	Lcin_1937	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine phosphatase.	0.881
glyA	glyA_2	Lcin_1342	Lcin_1083	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Serine hydroxymethyltransferase.	0.777
glyA	pssA	Lcin_1342	Lcin_2797	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	CDP-diacylglycerol-serine O-phosphatidyltransferase (phosphatidylserine synthase); Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.848
glyA	sdhL	Lcin_1342	Lcin_3088	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	L-serine dehydratase; Belongs to the iron-sulfur dependent L-serine dehydratase family.	0.921
glyA	serC	Lcin_1342	Lcin_3295	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.	0.542
glyA	trpA	Lcin_1342	Lcin_2508	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.	0.862
glyA	trpB	Lcin_1342	Lcin_2507	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.	0.862
glyA_2	Lcin_1937	Lcin_1083	Lcin_1937	Serine hydroxymethyltransferase.	Phosphoserine phosphatase.	0.688