Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
glsAGlutaminase; Belongs to the glutaminase family. (310 aa)    
Predicted Functional Partners:
gadB
Glutamate decarboxylase B, PLP-dependent; Belongs to the group II decarboxylase family.
  
 
 0.931
Lsai_2926
Glutamine synthase; Belongs to the glutamine synthetase family.
    
 0.920
glnA
Glutamine synthetase.
    
 0.920
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    
 0.919
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
     
 0.912
putA
Bifunctional PutA protein (proline dehydrogenase/ delta-1-pyrroline-5-carboxylate dehydrogenase); Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
   
 
 0.908
glmS
Glucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
     
 0.903
Lsai_0353
NADP-specific glutamate dehydrogenase.
     
  0.900
carB
Carbamoyl-phosphate synthase large subunit; Belongs to the CarB family.
     
  0.900
Lsai_2082
NAD-glutamate dehydrogenase.
     
  0.900
Your Current Organism:
Legionella sainthelensi
NCBI taxonomy Id: 28087
Other names: ATCC 35248, CCUG 29672, CIP 103885, DSM 19231, L. sainthelensi, NCTC 11988, strain MSH-4, strain Mt. St. Helens 4
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