AMN10684.1 protein (Alteromonas macleodii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AMN10684.1

Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (134 aa)

Predicted Functional Partners:

AMN10685.1

0.930

pstA

0.830

AMN11274.1

0.784

pstB

0.656

AMN11901.1

0.627

AMN11888.1

0.606

AMN10823.1

0.552

AMN10804.1

0.499

AMN11313.1

0.498

AMN11585.1

0.446

Your Current Organism:

Alteromonas macleodii

NCBI taxonomy Id: 28108
Other names: A. macleodii, ATCC 27126, Alteromonas sp. F12, CCUG 16128, CIP 103198, DSM 6062, JCM 20772, LMG 2843, LMG:2843, NBRC 102226, Pseudoalteromonas macleodii

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMN10684.1	AMN10685.1	ACZ81_03255	ACZ81_03260	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AMN10684.1	AMN10804.1	ACZ81_03255	ACZ81_03925	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.499
AMN10684.1	AMN10823.1	ACZ81_03255	ACZ81_04030	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
AMN10684.1	AMN11274.1	ACZ81_03255	ACZ81_06545	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.784
AMN10684.1	AMN11313.1	ACZ81_03255	ACZ81_06760	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.498
AMN10684.1	AMN11585.1	ACZ81_03255	ACZ81_08355	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Pilus assembly protein PilZ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.446
AMN10684.1	AMN11888.1	ACZ81_03255	ACZ81_10025	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.606
AMN10684.1	AMN11901.1	ACZ81_03255	ACZ81_10095	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.627
AMN10684.1	pstA	ACZ81_03255	ACZ81_04035	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.830
AMN10684.1	pstB	ACZ81_03255	ACZ81_04040	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.	0.656
AMN10685.1	AMN10684.1	ACZ81_03260	ACZ81_03255	Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.930
AMN10685.1	AMN10804.1	ACZ81_03260	ACZ81_03925	Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.593
AMN10685.1	AMN11313.1	ACZ81_03260	ACZ81_06760	Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.624
AMN10685.1	AMN11585.1	ACZ81_03260	ACZ81_08355	Derived by automated computational analysis using gene prediction method: Protein Homology.	Pilus assembly protein PilZ; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.698
AMN10685.1	AMN11888.1	ACZ81_03260	ACZ81_10025	Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.705
AMN10685.1	AMN11901.1	ACZ81_03260	ACZ81_10095	Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
AMN10804.1	AMN10684.1	ACZ81_03925	ACZ81_03255	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.499
AMN10804.1	AMN10685.1	ACZ81_03925	ACZ81_03260	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Derived by automated computational analysis using gene prediction method: Protein Homology.	0.593
AMN10823.1	AMN10684.1	ACZ81_04030	ACZ81_03255	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.552
AMN10823.1	pstA	ACZ81_04030	ACZ81_04035	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphate ABC transporter permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.987

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Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.851

expected number of edges:

10

PPI enrichment p-value:

3.1e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043953

Protein transport by the Tat complex

6 of 6

2.4

4.53

8.38e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008320

Protein transmembrane transporter activity

6 of 14

2.03

3.48

1.93e-08

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033281

TAT protein transport complex

6 of 6

2.4

4.97

8.51e-11

GO:0005887

Integral component of plasma membrane

6 of 55

1.44

1.93

1.18e-06

GO:0032991

Protein-containing complex

7 of 219

0.9

0.84

0.00011

GO:0071944

Cell periphery

9 of 600

0.57

0.47

0.00074

GO:0005886

Plasma membrane

8 of 507

0.6

0.46

0.0021

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:28848502

(2017) In silico Analyses of Subtype Specific HIV-1 Tat-TAR RNA Interaction Reveals the Structural Determinants for Viral Activity.

4 of 4

2.4

2.93

2.31e-06

PMID:24465566

(2014) Molecular and genetic characterization of natural HIV-1 Tat Exon-1 variants from North India and their functional implications.

4 of 4

2.4

2.93

2.31e-06

PMID:26880113

(2016) Inferences from tip-calibrated phylogenies: a review and a practical guide.

2 of 2

2.4

1.17

0.0070

PMID:24236045

(2013) Diversity and evolution of bacterial twin arginine translocase protein, TatC, reveals a protein secretion system that is evolving to fit its environmental niche.

2 of 7

1.85

0.79

0.0313

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4521

TAT protein transport complex

6 of 6

2.4

4.78

2.20e-10

CL:4509

TAT protein transport complex, and Copper ion binding

7 of 12

2.16

4.69

4.33e-11

CL:4352

Mixed, incl. Efflux transmembrane transporter activity, and RND efflux pump, membrane fusion protein

8 of 94

1.33

1.89

8.44e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mfa03060

Protein export

6 of 19

1.9

3.32

1.23e-08

mfa03070

Bacterial secretion system

6 of 33

1.66

2.59

1.10e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0033281

TAT protein transport complex

6 of 6

2.4

4.83

1.70e-10

GOCC:0005886

Plasma membrane

7 of 353

0.7

0.49

0.0077

GOCC:0032991

Protein-containing complex

7 of 443

0.6

0.38

0.0261

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0811

Translocation

6 of 14

2.03

3.66

6.34e-09

KW-0997

Cell inner membrane

7 of 108

1.21

1.44

3.85e-06

KW-1133

Transmembrane helix

8 of 566

0.55

0.39

0.0112

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00902

Sec-independent protein translocase protein (TatC)

2 of 2

2.4

0.75

0.0425

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003369

Sec-independent protein translocase protein TatA/B/E

4 of 4

2.4

2.59

1.13e-05

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