node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gltB | ilvA | Lxx11320 | Lxx16900 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | Threonine dehydratase; Identified by sequence similarity. | 0.847 |
gltB | ilvB | Lxx11320 | Lxx13200 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | Acetolactate synthase, large subunit; Identified by sequence similarity. | 0.681 |
gltB | ilvC | Lxx11320 | Lxx13170 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.880 |
gltB | ilvD | Lxx11320 | Lxx13210 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | Dihydroxy-acid dehydratase protein; Identified by sequence similarity; Belongs to the IlvD/Edd family. | 0.935 |
gltB | ilvN | Lxx11320 | Lxx13180 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | Acetolactate synthase, small subunit; Identified by sequence similarity. | 0.839 |
gltB | leuA | Lxx11320 | Lxx14490 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.571 |
gltB | leuB | Lxx11320 | Lxx13130 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.791 |
gltB | leuC | Lxx11320 | Lxx09660 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 3-isopropylmalate dehydratase (large subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.825 |
gltB | leuD | Lxx11320 | Lxx09680 | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 3-isopropylmalate dehydratase (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.789 |
ilvA | gltB | Lxx16900 | Lxx11320 | Threonine dehydratase; Identified by sequence similarity. | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 0.847 |
ilvA | ilvB | Lxx16900 | Lxx13200 | Threonine dehydratase; Identified by sequence similarity. | Acetolactate synthase, large subunit; Identified by sequence similarity. | 0.965 |
ilvA | ilvC | Lxx16900 | Lxx13170 | Threonine dehydratase; Identified by sequence similarity. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.732 |
ilvA | ilvD | Lxx16900 | Lxx13210 | Threonine dehydratase; Identified by sequence similarity. | Dihydroxy-acid dehydratase protein; Identified by sequence similarity; Belongs to the IlvD/Edd family. | 0.949 |
ilvA | ilvE | Lxx16900 | Lxx13120 | Threonine dehydratase; Identified by sequence similarity. | Branched-chain amino acid aminotransferase; Identified by sequence similarity. | 0.942 |
ilvA | ilvN | Lxx16900 | Lxx13180 | Threonine dehydratase; Identified by sequence similarity. | Acetolactate synthase, small subunit; Identified by sequence similarity. | 0.979 |
ilvA | leuA | Lxx16900 | Lxx14490 | Threonine dehydratase; Identified by sequence similarity. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.490 |
ilvA | leuB | Lxx16900 | Lxx13130 | Threonine dehydratase; Identified by sequence similarity. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.945 |
ilvA | leuD | Lxx16900 | Lxx09680 | Threonine dehydratase; Identified by sequence similarity. | 3-isopropylmalate dehydratase (small subunit); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.448 |
ilvB | gltB | Lxx13200 | Lxx11320 | Acetolactate synthase, large subunit; Identified by sequence similarity. | Glutamate synthase, alpha subunit; Identified by sequence similarity. | 0.681 |
ilvB | ilvA | Lxx13200 | Lxx16900 | Acetolactate synthase, large subunit; Identified by sequence similarity. | Threonine dehydratase; Identified by sequence similarity. | 0.965 |